法医学杂志

法医学杂志 ›› 2016, Vol. 32 ›› Issue (2): 131-133.DOI: 10.3969/j.issn.1004-5619.2016.02.013

• 综述 • 上一篇    下一篇

circRNA的研究进展及其法医学意义

张雅琪1，邵诚臣1，李成涛1，2，赵子琴1，谢建辉1   

  1. （1. 复旦大学基础医学院法医系，上海 200032； 2. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室，上海 200063）
  • 发布日期:2016-04-25 出版日期:2016-04-28
  • 通讯作者: 谢建辉，男，博士，副教授，博士研究生导师，主要从事法医遗传学研究；E-mail：jhxie@fudan.edu.cn
  • 作者简介:张雅琪（1989—），女，主要从事法医遗传学研究；E-mail：14211010071@fudan.edu.cn
  • 基金资助:

    国家自然科学基金资助项目（81222041、81571853）

Research Progress of circRNA and Its Significance in Forensic Science

ZHANG YA-QI1, SHAO CHENG-CHEN1, LI CHENG-TAO1,2, ZHAO ZI-QIN1, XIE JIAN-HUI1   

  1. （1. Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; 2. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063, China）
  • Online:2016-04-25 Published:2016-04-28

被引次数

4

摘要： RNA在法医学领域中越来越受到重视，发展以RNA为基础的新生物标记在复杂案例分析中具有重要的意义。环形RNA（circular RNA，circRNA）是最近被广泛报道的一类非编码RNA，虽然其生成和表达调节机制目前尚未完全清楚，但现有的研究表明circRNA具有重要的生物学功能。circRNA具有细胞表达特异性，稳定性好且表达丰富等特点，使其在法医学应用中具有潜在意义。本文对circRNA的研究历程及生成调节机制、生物学属性及其生物学功能进行总结，希望能为相关研究和法医学应用提供参考。

关键词: 法医遗传学, 环形RNA, 综述[文献类型]

Abstract: RNA has received more attention in the field of forensic medicine and the development of the new biological markers based on RNA shows great significance in the analysis of complex cases. circular RNA （circRNA） is a kind of non-coding RNA which is widely reported recently. Although the regulatory mechanisms of generation and expression are not fully clear, the existing research indicates that circRNA has important biological functions. CircRNA has a cell-type-specific expression with great stability and a high expression level, which makes it meaningful in forensic applications potentially. In this paper, the research progress, the generation and regulation of circRNA as well as its biological characteristics and functions are summarized, which will provide references for related studies and forensic applications.

Key words: forensic genetics, circRNA, review [publication type]

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