法医学杂志

法医学杂志 ›› 1992, Vol. 0 ›› Issue (3): 119-123+.

• 论文 • 上一篇    下一篇

大鼠脑震荡模型的建立及病理学研究

于晓军;赵福弟;刘卯阳;王兆辰;吴家馼;   

  1. 吉林医学院法医学教研室,吉林医学院法医学教研室,吉林医学院法医学教研室,吉林医学院法医学教研室,华西医科大学法医学系 吉林 132001,吉林 132001,吉林 132001,吉林 132001,成都 610041
  • 发布日期:1992-06-25 出版日期:1992-06-28

EXPERIMENTAL CEREBRAL CONCUSSION IN RAT AND ITS PATHOLOGICAL STUDIES

YU XIAOJUN ET AL DAPARTMENT OF FORENSIC MEDICINE, JILIN MEDICAL COLLEGE   

  • Online:1992-06-25 Published:1992-06-28

被引次数

55

摘要： 本文介绍用单摆式打击装置建立大鼠脑震荡模型。意识丧失1～6分钟,并迅速恢复而无定位性神经病学征象。打击时鼠头部吸收能量约2.35J。常规病理学检查发现脑组织有淤血、水肿和灶性出血。病变有明显的时序:脑震荡后15分钟脑血管痉挛;1小时开始出现淤血,水肿;6小时病变达到高峰,可见散在小出血灶;24小时恢复至1小时水平;48小时基本正常。Woil氏染色,显示弥漫性轴索、髓鞘肿胀;伤后6小时开始出现“收缩球”。病变以脑干、枕极、小脑、额极、海马及脑室壁等中线区为重。

关键词: 脑震荡, 意识模糊, 时序变化, 生物力学

Abstract: Cerebral concussion was produced with an iron pendulum hitting in rats, which resulted in loss of consciousness lasting 1 to 6 minutes The rat recovered soon without focal neurological signs The energy absorbed by the head at impact was calculated to be about 2.35 J. The routine pathological observation showed the changes of congestion, edema, and small focal hemorrhage in the brain tissues. A remarkable time course of pathological alterations were observed. After concussive injury, the brain vessels showed spasmodic contraction at 15 vain. The above nonidiosyncratic alterations began at 1h, reached a peak at 6h, retarned to the level of the 1h at 24h and disappeared at 48h. with weil's staining, swelling of the axons and the myelin sheaths were revealed. The lesions of retraction bails began to appear at 6h after injury and lasted to 24h and 48h.