法医学杂志 ›› 2002, Vol. 0 ›› Issue (4): 246-248.

• 论文 • 上一篇    下一篇

Y-染色体SNPs及其在法医学中的应用价值

应斌武,高玉振,张建华,周旭科,林伟,侯一平   

  1. 四川大学基础医学与法医学院,四川大学基础医学与法医学院,司法部司法鉴定中心,诸暨市公安局,成都市检察院,四川大学基础医学与法医学院 四川成都610041 ,四川成都610041 ,上海200063 ,浙江311800 ,四川610017 ,四川成都610041
  • 发布日期:2002-08-25 出版日期:2002-08-28

The research and application of Y-chromasomal SNPs in forensic science

YING BIN-WU 1 ,GAO YU-ZHEN 1 ,ZHANG JIAN-HUA 2 ,ET AL.(1.COLLEGE OF FORENSIC MEDICINE,SICHUAN UNIVERSITY,CHENGDU610041;2.INSTITUTE OF FORENSIC SCIENCES,MINISTRY OF JUSTICE,PRC,SHANGHAI200063)   

  • Online:2002-08-25 Published:2002-08-28

摘要: 随着人类基因组计划的迅猛发展,已有越来越多的Y染色体SNP位点被发现,在个人识别、家系谱的建立、疾病的预测与诊断方面,Y染色体单核苷酸多态性提供了非常有价值的遗传标记。同样在法医学中也有广阔的应用前景。本文综合介绍了SNP和Y-SNP的一般特性及在法医学中的应用价值。

关键词: Y-染色体, 单倍型, 单核苷酸多态性

Abstract: These variable sites of Y-chromosome are present at high density in the genome.Single Nucleotide Polymorphisms(SNPs)provide a valuable source of genetic markers for determining identity,establishing genetic linkages and predicting/diagnosing diseases.They are also found widespread application to the forensic medicine.This report mainly describe the SNPs and Y-chromosome SNPs characteristics and its potential applications to the forensic medicine.

Key words: Y-chromosome, haplotype, SNPs