法医学杂志

法医学杂志 ›› 2007, Vol. 0 ›› Issue (6): 444-445.

• 论文 • 上一篇    下一篇

中国北方汉族群体TPH基因座-T457C位点遗传多态性

关红玉;王保捷;丁梅;庞灏;王兵;吕洪涛;邢佳鑫;宣金锋;李春梅;   

  1. 中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院 辽宁沈阳110001,辽宁沈阳110001,辽宁沈阳110001,辽宁沈阳110001,辽宁沈阳110001,辽宁沈阳110001,辽宁沈阳110001,辽宁沈阳110001,辽宁沈阳110001
  • 发布日期:2007-12-25 出版日期:2007-12-28

Distribution of tryptophan hydroxylase Gene-T457C Locus Polymorphism in Han Ethnic Group in Northern China

GUAN HONG-YU, WANG BAO-JIE, DING MEI, PANG HAO, WANG BIN, LU HONG-TAO, XING JIA-XIN, YI JIN-FENG, LI CHUN-MEI (SCHOOL OF FORENSIC MEDICINE, CHINA MEDICAL UNIVERSITY, SHENYANG 110001, CHINA)   

  • Online:2007-12-25 Published:2007-12-28

被引次数

3

摘要： 目的研究色氨酸羟化酶(tryptophan hydroxylase,TPH)基因座-T457C位点在中国北方汉族群体中的遗传多态性及其法医学应用价值。方法应用PCR-RFLP、聚丙烯酰胺凝胶电泳及银染技术,检测180例北方汉族无关个体TPH基因座-T457C位点的遗传多态性。结果TPH基因座-T457C位点在中国北方汉族群体中,其个体识别能力(DP)为0.624,非父排除率(PE)为0.187,与法国人群基因频率比较差异显著(P<0.05)。结论TPH基因座-T457C位点在法医学中有重要应用价值,其遗传多态性可能存在民族或地域差异。

关键词: 法医学, TPH, 单核苷酸多态性

Abstract: Objective To study the distribution of the tryptophan hydroxylase(TPH) gene-T457C locus polymorphism in Han ethnic group in northern China and to find its applicable value in forensic science. Methods Genomic DNA samples, extracted from 180 unrelated individuals in northern Chinese Han population, were analyzed by PCR-RFLP. Results The discrimination power (DP) value and the power of exclusion (PE) value of the TPH gene-T457C locus were 0.624 and 0.187, respectively. The allele frequency showed significant difference from that of French people (P=0.04). Conclusion Polymorphism of the TPH gene-T457C locus could show ethnic and regional differences. It has a potential to be used in forensic science.

Key words: forensic science, tryptophan hydroxylase (TPH), single nucleotide polymorphism