法医学杂志

法医学杂志 ›› 2008, Vol. 0 ›› Issue (3): 175-177+.

• 论文 • 上一篇    下一篇

早期心肌缺血猝死心肌Ⅰ型胶原的表达

高淑红;刘聪;谭秋丰;黄飞骏;   

  1. 四川大学华西基础医学与法医学院,四川大学华西医院感染性疾病中心,四川大学华西基础医学与法医学院,四川大学华西基础医学与法医学院 四川成都610041,四川成都610041,四川成都610041,四川成都610041
  • 发布日期:2008-06-25 出版日期:2008-06-28

Expression of Myocardial CollagenⅠin Early Acute Myocardial Ischemic of Human

GAO SHU-HONG1, LIU CONG2, TAN QIU-FENG1, HUANG FEI-JUN1 (1. WEST CHINA SCHOOL OF PRECLINICAL AND FORENSIC MEDICINE, SICHUAN UNIVERSITY CHENDU 610041, CHINA; 2.CENTER OF INFECTIONS DISEASES, WEST CHINA HOSPITAL, SICHUAN UNIVERSITY CHENGDU 610041, CHINA)   

  • Online:2008-06-25 Published:2008-06-28

被引次数

3

摘要： 目的探讨Ⅰ型胶原蛋白在心肌早期缺血死后诊断中的法医学价值。方法将收集的案例心肌蜡块分为3组:正常对照组、早期心肌缺血组、心肌梗死组,用免疫组织化学技术(S-P法),观察猝死心肌内Ⅰ型胶原的表达情况,对其结果进行半定量分析。结果早期心肌缺血组和心肌梗死组心肌细胞质以及细胞核染色阳性,且早期心肌缺血组与心肌梗死组表达强度相近,说明早期心肌缺血组在胶原网结构方面已经发生与心肌梗死相同的改变。结论Ⅰ型胶原可以作为早期心肌缺血的一个诊断指标。

关键词: 法医病理学, 免疫组织化学, 心脏性猝死, Ⅰ型胶原

Abstract: Objective To estimate the significance of myocardial collagenⅠin the early acute myocardial ischemia of human. Methods The myocardial paraffin block had normal group, early myocardial ischemia group and myocardial infarction group. The myocardial collagenⅠwas observed with immunohistochemical staining and analyzed by half- quantity. Results The similar expression of collagen Ⅰ was observed in the cytoplasm and nucleolus in two groups. Conclusion The collagenⅠappeared in the myocardium of early acute myocardial ischemia of human. It may be an important index for postmortem diagnosis of the early acute myocardial ischemia.

Key words: forensic pathology, immunohistochemical staining, sudden cardiac death, collagen Ⅰ