法医学杂志

法医学杂志 ›› 2009, Vol. 0 ›› Issue (3): 176-178.

• 论文 • 上一篇    下一篇

乌头急性中毒死亡者乌头生物碱的体内分布

刘伟;沈敏;秦志强;   

  1. 复旦大学上海医学院法医学系;司法部司法鉴定科学技术研究所上海市法医学重点实验室;
  • 发布日期:2009-06-25 出版日期:2009-06-28

Distribution of Aconitum Alkaloids in the Corpse Died of Acute Aconite Intoxication

LIU WEI1,2,SHEN MIN2,QIN ZHI-QIANG2(1.DEPARTMENT OF FORENSIC MEDICINE,SHANGHAI MEDICAL COLLEGE,FUDAN UNIVERSITY,SHANGHAI 200032,CHINA;2.SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE,INSTITUTE OF FORENSIC SCIENCE,MINISTRY OF JUSTICE,P.R.CHINA,SHANGHAI 20006   

  • Online:2009-06-25 Published:2009-06-28

被引次数

13

摘要： 目的研究乌头急性中毒死亡者体液和组织中乌头生物碱的分布,为乌头中毒案的法医学鉴定取材和结果评价提供参考。方法用液相色谱-串联质谱法测定中毒死亡者体液和组织中乌头生物碱的含量。结果乌头碱在死者体液和组织中的含量从大到小依次为尿液、胆汁、胃内容物、心血、胰、心、肠、肝、肾、胃、肺、胆囊、脾,脑中未检出。结论尿液、胆汁和血液是检测体内乌头生物碱的较佳检材。

关键词: 法医毒理学, 乌头生物碱, 液相色谱-串联质谱法, 体内分布

Abstract: Objective To investigate the distribution of aconite alkaloids in biological fluids and tissues in the corpse died of acute aconite intoxication and to provide information for sample selection and result evaluation in forensic identification.Methods The content of aconite alkaloids in biological fluids and tissues were determined by liquid chromatography-tandem mass spectrometry.Results The content of aconite displayed in decending order of urine,bile,gastric content,heart blood,pancreas,heart,intestine,liver,kidney,stomach,lung,gallbladder and spleen,with no aconite detected in the brain.Conclusion It was indicated that urine,bile and blood are the best specimens for the determination of aconite in body of the acute aconite intoxication.

Key words: forensic toxicology, aconitum alkaloids, LC-MS/MS, tissue distribution