法医学杂志

法医学杂志 ›› 2010, Vol. 0 ›› Issue (1): 47-50.

• 论文 • 上一篇    下一篇

Alu家族在法医DNA分析中的应用

赵贵森;常林;莫耀南;   

  1. 中国政法大学证据科学教育部重点实验室;河南科技大学法医学院;
  • 发布日期:2010-02-25 出版日期:2010-02-28

Applications of Alu Family in Forensic DNA Analysis

ZHAO GUI-SEN,CHANG LIN,MO YAO-NAN(1.KEY LABORATORY OF EVIDENCE SCIENCE,CHINA UNIVERSITY OF POLITICAL SCIENCE AND LAW,MINISTRY OF EDU-CATION,BEIJING 100088,CHINA;2.SCHOOL OF FORENSIC MEDICINE,HENAN UNIVERSITY OF SCIENCE AND TECHNOLO-GY,LUOYANG 471003,CHINA   

  • Online:2010-02-25 Published:2010-02-28

摘要： Alu家族是灵长类特有的短散在重复序列,在人类基因组内含量丰富,分布广泛,甲基化程度高,有种属特异性和插入变异,为法医DNA分析面临的许多问题提供了潜在的解决途径。目前,Alu元件在法医DNA分析中的应用包括:DNA定量、种属鉴定、种族鉴定、性别鉴定、个体识别和亲子鉴定,以及全基因组扩增等。本文总结各种基于Alu元件的法医DNA分析技术的原理和特点,探讨Alu元件的法医学研究和应用前景,供相关学者参考。

关键词: 法医遗传学, Alu元件, 综述[文献类型

Abstract: Alu family is the primate specific short interspersed repetitive elements(SINEs).Its abundance and diversity distribution in genome,high methylation level and polymorphic for insertion make them ide-ally suitable as tools in forensic applications.The application of Alu sequence in forensic genomics,in-clude DNA quantitation,race determination,species and gender identification,personal identification,paternity testing and whole-genome amplification.The principles and characteristics of these Alu-based techniques are also summarized.The prospect of Alu as forensic molecular marker is discussed as well.

Key words: forensic genetics, Alu elements, review[publication type]