法医学杂志

法医学杂志 ›› 2018, Vol. 34 ›› Issue (6): 640-643.DOI: 10.12116/j.issn.1004-5619.2018.06.013

• 论著 • 上一篇    下一篇

脑外伤后情绪障碍者面孔表情ERP晚期正成分分析

董日霞，杜向东，杨建功，王晓龙，吴天诚，徐晓文，朱宏亮   

  1. 苏州市广济医院，江苏 苏州 215008
  • 发布日期:2018-12-25 出版日期:2018-12-28
  • 作者简介:董日霞（1983—），女，主检法医师，主要从事神经电生理及精神病司法鉴定研究；E-mail：88608220@qq.com
  • 基金资助:
    苏州市科技计划指导性资助项目（SYSD2014131）；苏州市精神疾病临床医学中心资助项目（Szzx201509）；苏州市重点学科资助项目（Szxk201515）

Analysis of Late Positive Component of Event-related Potentials by Face Expression Images in Traumatic Brain Injury Patients with Mood Disorders

DONG Ri-xia, DU Xiang-dong, YANG Jian-gong, WANG Xiao-long, WU Tian-cheng, XU Xiao-wen, ZHU Hong-liang   

  1. Suzhou Psychiatric Hospital, Suzhou 215008, Jiangsu Province, China
  • Online:2018-12-25 Published:2018-12-28

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摘要： 目的 探讨正性、负性及中性面孔刺激范式事件相关电位（event-related potential，ERP）在脑外伤者情绪障碍评定中的应用价值。 方法 对24例以焦虑忧郁症状为主的情绪障碍者（忧郁组）和19例以敌对猜疑症状为主的情绪障碍者（敌对组）分别进行面孔刺激范式ERP检测，比较其与正常对照组的差异。 结果 正性、负性和中性3类图片刺激诱发的ERP晚期正成分（late positive potential，LPP）潜伏期及波幅（负性图片刺激诱发的波幅除外）在忧郁组及敌对组间差异均无统计学意义，两组LPP潜伏期较正常对照组均延长，LPP波幅较正常对照组均降低。在相同组内，3类图片刺激诱发的LPP潜伏期差异无统计学意义，负性图片刺激诱发的LPP波幅均高于中性、正性图片刺激诱发的LPP波幅，敌对组与正常对照组波幅差异具有统计学意义（P<0.05），而忧郁组内波幅差异无统计学意义。 结论 LPP潜伏期、波幅的变化可作为脑外伤者情绪障碍评定的客观指标，负性情绪诱发的LPP对忧郁为主的情绪障碍的评估更有意义。

关键词: 司法精神病学, 情绪障碍, 事件相关电位, 晚期正成分

Abstract: Objective To explore the application of event-related potentials （ERP） by positive, negative, and neutral face expression images in the evaluation of mood disorders in brain traumatic patients. Methods ERP was tested by face expression images in 24 patients mainly with anxiety and depression symptoms （depression group） and 19 patients mainly with hostile and suspicion symptoms （hostile group）, respectively. The findings were compared with those of the control group. Results There were no significant differences, between the depression group and the hostile group, on latencies and amplitudes of late positive potential （LPP） induced by the three types of face expression images, except the amplitude induced by negative face expression image. Compared with the control group, the latencies were extended and the amplitudes were lower in both depression and hostile groups. Within each group, the difference of latencies induced by the three images was not significant. The amplitudes induced by negative face expression image was higher than those induced by positive and neutral face expression images, with significant differences in the hostile group and the control group （P<0.05） but not in the depression group. Conclusion Changes in latencies and amplitudes of LPP could be an objective indicator in the evaluation of mood disorders of brain traumatic patients. The LPP induced by negative face expression images could be more meaningful for patients mainly with anxiety and depression symptoms.

Key words: forensic psychiatry, mood disorders, event-related potentials, late positive potential