The Latest Research Progress on Cell-Free DNA and Prospects of Its Forensic Application

doi:10.12116/j.issn.1004-5619.2022.521001

Abstract

Abstract:

In recent years， with the continuous progress of DNA extraction and detection technology， cell-free DNA（cfDNA）has been widely used in the life science field， and its potential application value in forensic identification is becoming more and more obvious. This paper reviews the concept， formation mechanism， and classification of cfDNA，etc.， and describes the latest research progress of cfDNA in personal identification of crime scene touch DNA samples and non-invasive prenatal paternity testing （NIPPT）. Meanwhile， this paper summarizes the potential application of cfDNA in injury inference， and discusses the advantages and disadvantages of common cfDNA analysis methods and techniques， and its application prospects， to provide a new idea for the wide application of cfDNA in the field of forensic science.

Key words: forensic genetics, cell-free DNA, touch DNA, non-invasive prenatal paternity testing, individual identification, paternity, review

CLC Number:

Wen-jing HU, Ting-ting YANG, Ya-ya WANG, Jiang-wei YAN. The Latest Research Progress on Cell-Free DNA and Prospects of Its Forensic Application[J]. Journal of Forensic Medicine, 2024, 40(1): 70-76.

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