An immunohistochemical study on the distribution in organs in cases with morphine poisioning

Abstract

Abstract: Objective To investigate the distribution of mophine in organs in cases with morphine poisioning to select ideal organs for immunohistochemical derection. Methods Localization and half quantitation of morphine in the brain, the kidney, the heart,and the liver were studied in 8 cases with morphine poisoning by immunohistochemical SP method. Results Morphine was mainly detected in the cytoplasm of certain parenchymal cells of the organs. The distribution varied greatly with different cases and organs. In the brain and kidney, morphine-positive cells could be easily found. Conclusion The kidney and brain may be the ideal organs for sampling in suspected morphine poisoning cases with.

Key words: morphine, distribution, immunohistochemistry

SHAN YA-MING;HAO CHUN-YU;WANG LONG;ET AL. (SHENYANG CRIMINAL SCIENCE AND TECHNOLOGY INSTITUTE;SHENYANG 000). An immunohistochemical study on the distribution in organs in cases with morphine poisioning[J]. , 2002, 0(1): 9-11.

[1]	Yan WEN, Yu-zhe HAN, Duo GONG, Wen-kai XIE, Chen-xi LÜ, Yu-zhen MENG, Chao ZHANG, Zhi-wen WEI, Ke-ming YUN. Postmortem Distribution and Postmortem Redistribution of Carbofuran-7-Phenyl Glucuronic Acid in Rabbits [J]. Journal of Forensic Medicine, 2022, 38(5): 601-605.
[2]	Hui YAN, Meng DU, Zheng QIAO, Ping XIANG, Bao-hua SHEN, Min SHEN, Wei LIU. Analysis of the Distribution of Total Phosphine and the Characteristics of Phosphine Poisoning in 29 Victims [J]. Journal of Forensic Medicine, 2022, 38(2): 254-257.
[3]	Xue-shi CHEN, Jun CHU, Li-jun YANG, Tao WANG, Lu-yang TAO. Application of Immunohistochemistry and Special Staining Technique in Forensic Traumatic Pathology Identification [J]. Journal of Forensic Medicine, 2021, 37(5): 666-672.
[4]	MA Guan-ju, LI Shu-jin. Calculation of the Probability Distribution of CIBS Score in Different Relationships and Its Application [J]. Journal of Forensic Medicine, 2021, 37(3): 372-377.
[5]	WU Mao-wang, SU Li, HE Fang, et al. Differential Expression of Integrin β1 in Two Brain Injury Models of Rats [J]. 法医学杂志, 2020, 36(4): 502-506.
[6]	MIN Tao, LIU Shao-dan, XIN Guo-bin, et al.. Retention Time and Ion Abundance Ratio of 8 Common Drugs （Poisons） by LC-MS/MS Qualitative Analysis#br# [J]. 法医学杂志, 2020, 36(2): 216-222.
[7]	ZHAO Qi, LI Ran, JIN Yun-zhou, et al.. Equation Derivation of the Probability Distribution of IBS Score among Full Sibling Pairs [J]. 法医学杂志, 2019, 35(6): 657-661.
[8]	LIU Meng-yan, LIU Yan-lei, WU Ping,et al.. Determination of Place of Residence Using the Gene Information of Plants Carried by the Human Body [J]. 法医学杂志, 2019, 35(6): 710-715.
[9]	CHEN Jing-wei, WANG Peng-fei, ZHANG Meng-zhou1，et al.. Relationship between Expression Changes of CB2R and Wound Age of Brain Contusion in Mice [J]. 法医学杂志, 2019, 35(2): 136-142.
[10]	ZHAO Jian-xin, JIN Xin, HUANG Jun-jie，et al.. Time-dependent Expression and Distribution of AChE during the Skin Incised Wound Healing in Mice [J]. 法医学杂志, 2019, 35(2): 143-148.
[11]	ZHAO Huan-dong, ZHAO Shu-min, CHEN Yu-xiang, et al.. Formula Derivation for the Probability Distribution of IBS Score in Unrelated Individual Pairs [J]. 法医学杂志, 2018, 34(4): 370-374.
[12]	TANG WEI-WEI, LIN YU-CAI, LU YAN-XU. Biodistribution and Postmortem Redistribution of Emamectin Benzoate in Intoxicated Mice [J]. , 2016, 32(1): 26-30.
[13]	LIU DONG-MEI, ZHOU SHU, CHEN JIE-MIN, ET AL.. Distribution of Formic Acid after Methanol Intoxication in Rats [J]. 法医学杂志, 2015, 31(6): 450-453.
[14]	LUO LIANG-MING, WU YU-FENG, NI WEI-CHENG, ET AL.. Expression of GAP－43 in Midbrain Ventral Tegmental Area of Morphine Withdrawal Rats [J]. , 2013, 29(5): 330-332,336.
[15]	BU JUN, ZHAN CHANG-SHU. Comparison of Morphine and Codeine Concentration in Urines of Heroin Abusers and Codeine Users [J]. , 2012, 28(6): 426-428.

An immunohistochemical study on the distribution in organs in cases with morphine poisioning

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics