法医学杂志

法医学杂志 ›› 2021, Vol. 37 ›› Issue (4): 505-510.DOI: 10.12116/j.issn.1004-5619.2020.300501

所属专题： 新精神活性物质

• 专题 • 上一篇    下一篇

合成大麻素类新精神活性物质4F-MDMB-BUTINACA和MDMB-4en-PINACA的检测

王跨陡1， 袁晓亮2， 张玉荣1， 胡钧健2， 曹芳琦2， 陈永生1   

  1. 1. 上海市公安局物证鉴定中心，上海 200083； 2. 上海市刑事科学技术研究院，上海 200083
  • 发布日期:2021-08-25 出版日期:2021-08-28
  • 作者简介:王跨陡（1970—），男，副主任法医师，主要从事毒品、毒物分析检测研究；E-mail：wangkd001@163.com
  • 基金资助:
    国家自然科学基金青年科学基金资助项目（81701864）；上海市优秀学术带头人计划资助项目（19XD1432700）；上海市青年科技启明星计划资助项目（18QB1403400）；上海市自然科学基金探索类项目（17ZR1441600）

Identification of Synthetic Cannabinoid New Psychoactive Substances 4F-MDMB-BUTINACA and MDMB-4en-PINACA

WANG Kua-dou1, YUAN Xiao-liang2, ZHANG Yu-rong1, HU Jun-jian2, CAO Fang-qi2, CHEN Yong-sheng1   

  1. 1. Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China; 2. Shanghai Research Institute of Criminal Science and Technology, Shanghai 200083, China
  • Online:2021-08-25 Published:2021-08-28

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摘要： 目的 建立联合傅里叶变换红外光谱（Fourier transform infrared spectrum，FTIR）、气相色谱-质谱（gas chromatography-mass spectrometry，GC-MS）、高分辨质谱和核磁共振波谱（nuclear magnetic resonance spectroscopy，NMR）多种技术鉴定可疑未知物的方法。 方法 对实际案件中缴获的可疑检材（灰白色粉末和黄色晶体）分别采用FTIR、GC-MS（溶剂为甲醇）、高分辨质谱（溶剂为甲醇）及NMR（溶剂为氘代甲醇）方法进行检测。 结果 GC-MS测得样品中主要组分的质谱特征离子m/z分别为219（基峰）、363、307、304、275、145、131和213（基峰）、357、301、298、269、185、171、145、131，高分辨质谱实测的精确质量数[M+H]+分别为364.203 61和358.212 34。经查阅资料和数据库检索比对再结合红外分析和质谱数据分析，可判断未知样品为合成大麻素类新精神活性物质2-[1-（4-氟丁基）-1H-吲唑-3-甲酰氨基]-3，3-二甲基丁酸甲酯（4F-MDMB-BUTINACA）和3，3-二甲基-2-[1-（4-戊烯-1-基）-1H-吲唑-3-甲酰氨基]丁酸甲酯（MDMB-4en-PINACA），并采用1H-NMR对其结构进行了确证。 结论 建立的多技术联合鉴定方法能用于未知样品中4F-MDMB-BUTINACA和MDMB-4en-PINACA的鉴定。该方法快速、方便、准确、可靠、实用，能够对今后涉及此类物质的案件鉴定提供参考依据。

关键词: 法医学, 毒物分析, 新精神活性物质, 傅里叶变换红外光谱, 气相色谱-质谱法, 高分辨质谱法, 核磁共振波谱法, 合成大麻素

Abstract: Objective To establish a method that combines a series of techniques including Fourier transform infrared spectrum （FTIR）, gas chromatography-mass spectrometry （GC-MS）, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy （NMR） for identification of unknown substances. Methods The unknown samples （off-white powder and yellow crystal） seized in the actual cases were detected by FTIR, GC-MS （methanol as solvent）, high resolution mass spectrometry （methanol as solvent） and NMR （deuterated methanol as solvent）. Results The mass spectrum characteristic ions m/z of the main components in the samples measured by GC-MS were 219 （base peak）, 363, 307, 304, 275, 145, 131 and 213 （base peak）, 357, 301, 298, 269, 185, 171, 145 and 131, respectively. The accurate mass numbers [M+H]+ measured by high resolution mass spectrometry were 364.203 61 and 358.212 34, respectively. The unknown samples were identified as synthetic cannabinoid new psychoactive substances 4F-MDMB-BUTINACA and MDMB-4en-PINACA after data consultation and database retrieval and comparison, combined with infrared analysis and mass spectrometry data analysis, and their structures were confirmed by 1H-NMR. Conclusion The established multi-technology joint identification method can be used to identify 4F-MDMB-BUTINACA and MDMB-4en-PINACA in unknown samples. This method is fast, convenient, accurate, reliable and practical, and can provide reference for the identification of cases involving such substances in the future.

Key words: forensic medicine, toxicological analysis, new psychoactive substance, Fourier transform infrared spectrum （FTIR）, gas chromatography-mass spectrometry （GC-MS）, high resolution mass spectrometry, nuclear magnetic resonance spectroscopy （NMR）, synthetic cannabinoid

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