法医学杂志 ›› 2012, Vol. 28 ›› Issue (6): 456-460,463.DOI: 10.3969/j.issn.1004-5619.2012.06.015

• 综述 • 上一篇    下一篇

血液和尿液中元素ICP-MS分析研究进展

张素静1,2,卓先义2,马  栋2   

  1. (1. 苏州大学医学部药学院,江苏 苏州 215123; 2. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室,上海 200063)
  • 发布日期:2012-12-25 出版日期:2012-12-28
  • 通讯作者: 马栋,男,助理研究员,主要从事毒物分析研究;E-mail:madong@ssfjd.cn
  • 作者简介:张素静(1986—),女,河北石家庄人,硕士研究生,主要从事毒物分析研究;E-mail:ivy-yuonly@163.com
  • 基金资助:

    “十二五”国家科技支撑计划项目(2012BAK16B02、2012BAK26B06);上海市法医学重点实验室资助项目(12DZ22 71500)

Developments in Determination of Elements Using ICP-MS in Blood and Urine

ZHANG SU-JING1,2, ZHUO XIAN-YI2, MA DONG2   

  1. (1. School of Pharmacy, Medical College of Soochow University, Suzhou 215123, China; 2. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063, China)
  • Online:2012-12-25 Published:2012-12-28

摘要: 电感耦合等离子体质谱法(inductively coupled plasma-mass spectrometry,ICP-MS)是目前最常用的元素分析技术,具有灵敏度高、测量线性范围宽等优点,可进行血液、尿液中多元素同时分析。本文主要综述了ICP-MS的常见样品前处理方法(直接稀释法和湿法消解法)、对于质谱干扰和非质谱干扰的校正、影响分析结果准确度的主要因素,并对ICP-MS在法医毒物分析中的应用进行了展望。

关键词: 法医毒理学, 电感耦合等离子体质谱法, 综述[文献类型], 元素, 血液, 尿液

Abstract: Inductively coupled plasma-mass spectrometry (ICP-MS) is the most common technique for elements analysis at present. ICP-MS with high sensitivity and wide linear range can be applied to multi-elements analysis in blood and urine. This paper reviews the common means of sample pretreatment (direct dilution method and wet digestion method), the method for correction of mass spectral interference and non-interference, the main influence factors of analysis results, and provides an outlook of the application of ICP-MS in forensic toxicological analysis.

Key words: forensic toxicology, inductively coupled plasma-mass spectrometry(ICP-MS), review[publication type], elements, blood, urine

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