法医学杂志

法医学杂志 ›› 2013, Vol. 29 ›› Issue (3): 180-184.DOI: 10.3969/j.issn.1004-5619.2013.03.006

• 论著 • 上一篇    下一篇

X-STR分型用于亲缘关系鉴定的似然率计算

张胤鸣1，李  莉2，孙宏钰1   

  1. （1. 中山大学中山医学院法医学系，广东 广州 510080； 2. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室，上海 200063）
  • 发布日期:2013-06-25 出版日期:2013-06-28
  • 通讯作者: 孙宏钰，女，教授，主要从事法医物证学研究；E-mail：sunhongyu2002@163.com
  • 作者简介:张胤鸣（1986—），男，山东莱西人，硕士研究生，主要从事法医物证学研究；E-mail：fayizym@163.com
  • 基金资助:

    国家自然科学基金资助项目（81273347）

Calculation of Likelihood Ratio for X-STR Typing in Kinship Testing

ZHANG YIN-MING1, LI LI2, SUN HONG-YU1   

  1. （1. Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; 2. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, Shanghai 200063, China）
  • Online:2013-06-25 Published:2013-06-28

被引次数

2

摘要： 目的 推导X染色体短串联重复序列（X-short tandem repeat，X-STR）分型用于两个体间亲缘关系鉴定的似然率计算公式。 方法 根据不同亲缘关系的两个体间的血缘同一系数获得两个体特定的联合基因型概率（X值），计算两无关个体特定的联合基因型概率（Y值），从而求得似然率（X/Y）。 结果 推导出女性-女性、女性-男性、男性-男性个体间不同亲缘关系各种基因型组合的似然率计算公式，并通过案例验证。 结论 推导的根据X-STR分型计算两个体间亲缘关系的似然率计算方法简便、准确，为X-STR基因座在疑难亲缘关系鉴定中发挥其更大应用价值奠定了基础。

关键词: 法医遗传学, X染色体, 亲子关系, 短串联重复序列, 似然率

Abstract: Objective To deduce the calculation formulae of likelihood ratio for kinship testing with X-short tandem repeat （X-STR） typing. Methods With the identity by decent coefficient of different relationships, the joint genotypic probability of two individuals with specific genotypes was calculated as X value, and then the joint genotypic probability of two unrelated individuals was calculated as Y value; therefore, the likelihood ratio value（X/Y） was obtained. Results The calculation formulae of the likelihood ratio for different genotype combinations of the female-female, female-male and male-male genetic relationships were derived and verified by real cases. Conclusion The calculation formulae are simple and accurate to evaluate the likelihood ratio for two individuals’ genetic relationship with X-STR typing. The formulae provide the basic potential value for the difficult kinship testing with X-STR loci.

Key words: forensic genetics, X chromosome, parent-child relations, short tandem repeat, likelihood ratio

中图分类号: