法医学杂志

法医学杂志 ›› 2014, Vol. 30 ›› Issue (5): 329-331.DOI: 10.3969/j.issn.1004-5619.2014.05.003

• 论著 • 上一篇    下一篇

双手第1骨间背侧肌代谢物的氢质子磁共振波谱

吴轶慧1，杨  波2，王  涛3，贾建长1，嵇  鸣2，叶春涛2，沈忆文1   

  1. （1. 复旦大学基础医学院法医学系，上海 200032； 2. 复旦大学附属华东医院放射科，上海 200040； 3. 复旦大学附属华山医院手外科，上海 200040）
  • 发布日期:2014-10-25 出版日期:2014-10-28
  • 通讯作者: 沈忆文，女，博士，副教授，主要从事法医病理学、法医临床学教学及研究；E-mail：shenyiwen@fudan.edu.cn 嵇鸣，女，主任医师，硕士研究生导师，主要从事放射医学研究；E-mail：jiming@sh163.net
  • 作者简介:吴轶慧（1989—），女，上海人，硕士研究生，主要从事法医临床学研究；E-mail：12211010057@fudan.edu.cn
  • 基金资助:

    国家自然科学基金资助项目（81072512）

1H-MRS Study on the Metabolites of First Dorsal Interossei

WU YI-HUI1, YANG BO2, WANG TAO3, JIA JIAN-ZHANG1, JI MIN2, YE CHUN-TAO2, SHEN YI-WEN1   

  1. （1. Department of Forensic Medicine, School of Basic Medicine Sciences, Fudan University, Shanghai 200032, China; 2. Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China; 3. Hand Surgery of Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China）
  • Online:2014-10-25 Published:2014-10-28

被引次数

2

摘要： 目的 探讨氢质子磁共振波谱（1H-magnetic resonance spectroscopy，1H-MRS）检测技术在尺神经损伤预后评估的应用前景。 方法 对12例健康青年志愿者、1例尺神经完全损伤者双手第1骨间背侧肌的代谢物进行1H-MRS检测，对采集到的数据进行统计分析。 结果 健康女性成年人第1骨间背侧肌的细胞外脂质（extra-myocellular lipids，EMCL）峰下面积高于男性（P<0.05），胆碱、肌酸、细胞内脂质（intra-myocellular lipids，IMCL）在两性间差异均无统计学意义（P>0.05），双手间各峰下面积差异均无统计学意义（P>0.05）。尺神经损伤者患侧EMCL峰较健侧偏高，且FDI面积缩小。 结论 1H-MRS对肌肉代谢物的无创性以及定量检测对周围神经损伤的预后评估具有一定价值。

关键词: 法医学, 磁共振波谱学, 氢质子磁共振波谱, 尺神经, 第1骨间背侧肌

Abstract: Objective To estimate the application of prognosis evaluation of ulnar nerve injury by 1H-magnetic resonance spectroscopy （1H-MRS）. Methods The metabolites of first dorsal interossei （FDI） of two hands from 12 healthy volunteers and 1 volunteer with complete ulnar nerve injury were detected by 1H-MRS and the data were statistically analyzed. Results For the FDI of healthy adults, the female peaks area of extra-myocellular lipids （EMCL） was higher than the male （P<0.05）; There was no significant difference in Cho, Cr and intra-myocellular lipids （IMCL） between male and female （P>0.05）; There was no significant difference in all the peaks area between the left and right hand （P>0.05）. The EMCL peak of the injury side was higher than that of the healthy side, and the area of FDI was reduced in the volunteer with ulnar nerve injury. Conclusion Noninvasive and quantitative detection of 1H-MRS may be valuable for prognosis evaluation of peripheral nerve injury.

Key words: forensic medicine, magnetic resonance spectroscopy, 1H-MRS, ulnar nerve, first dorsal interosseous muscle

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