法医学杂志 ›› 2009, Vol. 0 ›› Issue (1): 63-67.

• 论文 • 上一篇    下一篇

乙基葡萄糖醛酸苷的检测及其在法医毒理学中的应用

赵晖;卓先义;沈保华;   

  1. 复旦大学上海医学院;司法部司法鉴定科学技术研究所上海市法医学重点实验室;
  • 发布日期:2009-02-25 出版日期:2009-02-28

Detection and Application of Ethyl Glucuronide in Forensic Toxicology

ZHAO HUI1, 2, ZHUO XIAN-YI2, SHEN BAO-HUA2 (1. SHANGHAI MEDICAL COLLEGE OF FUDAN UNIVERSITY, SHANGHAI 200032, CHINA; 2. SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE, INSTITUT OF FORENSIC SCIENCE, MINISTRY OF JUSTICE, P.R.CHINA, SHANGHAI 200063, CHINA)   

  • Online:2009-02-25 Published:2009-02-28

摘要: 乙基葡萄糖醛酸苷(ethylgl ucuronide,EtG)是乙醇在人体内的特异性代谢物。迄今,已有相当数量的文献针对EtG的检测方法、代谢动力学及实际应用等进行了深入探讨。本文综述了EtG的各种检测方法、EtG含量与乙醇摄入量的相互关系以及如何利用EtG含量区分是否酗酒、判断尸体中乙醇来源等,阐述EtG在法医毒理学领域的重要意义。

关键词: 法医毒理学, 乙醇特异性代谢物, 综述[文献类型], 乙基葡萄糖醛酸苷

Abstract: Ethyl glucuronide is a specific metabolite of ethanol. There have been plenty of articles refer- ring its pharmacokinetics, detection and application as a specific bio-marker of alcohol intake. This article reviews various analytical methods of EtG, relationship between EtG quantification and ethanol intake, and criteria for determining chronic alcohol abuse, and origin of ethanol found in the cadavers by EtG analysis. EtG has its potential application in forensic toxicology.

Key words: forensic toxicology, specific metabolite of ethanol, review[publication type], ethyl glucuronide