法医学杂志

法医学杂志 ›› 1999, Vol. 15 ›› Issue (4): 208-210+.

• 论文 • 上一篇    下一篇

GC/MS研究海洛因代谢物在吸毒者体内的分布

向平,沈敏,吴何坚,黄仲杰   

  1. 司法部司法鉴定科学技术研究所!上海,200063,司法部司法鉴定科学技术研究所!上海,200063,司法部司法鉴定科学技术研究所!上海,200063,司法部司法鉴定科学技术研究所!上海,200063
  • 发布日期:1999-08-25 出版日期:1999-08-28

Determination of heroin metabolites in biological fluids,tissues and hair of heroin addicts using GC/MS-SIM

XIANG PING; SHEN MIN; WU HEJIAN; ET AL. (INSTITUTE OFFORENSIC SCISNCES, MINISTRY OF JUSTICE, SHANGHAI200063, P. R. CHINA)   

  • Online:1999-08-25 Published:1999-08-28

被引次数

12

摘要： 应用GC／MS－SIM测定了海洛因代谢物吗啡在两例海洛因延缓死亡者的体内分布，并分析了收集到的7例案子的毛发（头发、腋毛和阴毛）中6-单乙酰吗啡和吗啡含量。生物检材和毛发经酸水解、提取、醋酸酐或双（三甲基硅基）三氟乙酰胺（BSTFA）衍生化，然后进行GC／MS-SIM分析。结果表明尿、胆汁和肝脏是判定死者是否曾使用海洛因的最佳检材；毛发分析与生物检材相比有其独特的优点，可提供数月甚至数年的用药情况。为公安司法机关打击吸毒、惩治犯罪提供更可靠、有效的证据。

关键词: GC／MS－SIM, 体液, 组织, 毛发, 代谢物, 吗啡, 6-单乙酰吗啡, 衍生化

Abstract: Using GC/MS - SIM, we examined morPhine distribution in human bodies of 2 delayed death cases and analyzed content of morphine and 6 - acetylmorphine (MAM) in hair specimens of 7 cases. Afer hydrolysis and extraction, MoR and 6 - MAM were derived with acetic anhydride or BSTFA and then the derivatives were qualitatively and quantitatively analyzed by GC/MS SIM. The results indicated that urine, bile and liver were the best samples to reveal the heroin - related deaths. Hair analysis has its unique advantage for its long time of abusing monitor, compared to biological fluids.

Key words: GC/MS-SIM, biological fluid, tissue, hair, metabolite, derivative, 6-acetylmorphine morphine