法医学杂志

法医学杂志 ›› 2008, Vol. 0 ›› Issue (4): 293-296.

• 论文 • 上一篇    下一篇

曲马多中毒及其毒理作用

王华新;王玲;官大威;王明彪;   

  1. 中国医科大学法医学院法医病理学教研室;辽宁省人民检察院技术处;
  • 发布日期:2008-08-25 出版日期:2008-08-28

Tramadol Intoxication and Its Toxicological Effect

WANG HUA-XIN1,2,WANG LING1,GUAN DA-WEI1,WANG MING-BIAO3(1.DEPARTMENT OF FORENSIC PATHOLOGY,SCHOOL OF FORENSIC MEDICINE,CHINA MEDICAL UNIVERSITY,SHENYANG 110001,CHINA;2.DEPARTMENT OF PATHOLOGY AND MEDICAL SCIENCE,COLLEGE OF BASIC MEDICAL SCIENCES,DALIAN ME   

  • Online:2008-08-25 Published:2008-08-28

被引次数

30

摘要： 曲马多为中枢非麻醉镇痛药,通过作用于μ阿片受体、抑制去甲肾上腺素与5-羟色胺再摄取等双重作用机制的协同作用,镇痛效果较好。在世界范围内被广泛应用于中、重度急、慢性疼痛的治疗。但目前有关曲马多不良反应与曲马多滥用中毒的案例报道正日益增多。本文从曲马多的镇痛机制、不良反应以及依赖滥用等方面,综述了导致曲马多中毒的可能因素,以期唤起人们对曲马多安全性的注意。

关键词: 法医毒理学, 中毒, 综述[文献类型], 药物滥用, 曲马多

Abstract: Tramadol is a centrally acting analgesic with a dual mode of action.Its analgesic efficacy is attributed to its partial affinity for the μ-opiate receptor and its inhibition of norepinephrine and serotonin reuptake.Acting in a synergistic manner and being more efficacious,tramadol is used worldwide for the treatment of moderate to severe acute or chronic pain.Abuse and dependence of tramadol as well as tramadol-related deaths have been increasingly reported,either ingested alone or taken in combination with other potentially interacting drugs.The possible toxic effect of tramadol was reviewed from aspects of its analgesic mechanisms,adverse effect,dependence,and abuse.

Key words: forensic toxicology, intoxication, review publication type, drug dependence, tramadol