法医学杂志

法医学杂志 ›› 2010, Vol. 0 ›› Issue (1): 30-32.

• 论文 • 上一篇    下一篇

艾司唑仑对人体神经行为能力的影响

卜俊;卓先义;   

  1. 司法部司法鉴定科学技术研究所上海市法医学重点实验室;
  • 发布日期:2010-02-25 出版日期:2010-02-28

The Influence of Estazolam on Human Neurobehavioral Function

BU JUN,ZHUO XIAN-YI(SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE,INSTITUTE OF FORENSIC SCIENCE,MINISTRY OF JUSTICE,P.R.CHI-NA,SHANGHAI 200063,CHINA)   

  • Online:2010-02-25 Published:2010-02-28

被引次数

10

摘要： 目的研究人体血液中艾司唑仑质量浓度和神经行为能力的关系。方法采用汉化第三版计算机化神经行为测试系统(NES-C3)和人体平衡功能测试仪(SMART Equi Test誖),通过自身对照的方式,对10名服用艾司唑仑者进行神经行为能力和平衡功能测试。结果受试者神经行为能力指数和平衡功能能力指数于服药后1h开始下降,服药后3h降到最低,服药后6h部分神经行为能力得到恢复,服药后10 h神经行为能力全部恢复。结论人体血液中艾司唑仑质量浓度为20ng/mL时,可损害驾驶能力。当艾司唑仑质量浓度达到40ng/mL以上时,人体神经行为能力严重下降。相同的艾司唑仑质量浓度在吸收阶段对人体的影响大于代谢阶段。

关键词: 法医毒理学, 艾司唑仑, 神经行为学表现

Abstract: Objective To study the relation between human blood estazolam concentration and neurobehavioral function.Methods The neurobehavioral ability of 10 volunteers were measured with computer-administered neurobehavioral evaluation system-chinese3(NES-C3) and SMART EquiTest system.Results The neurobe-havioral ability and balance function declined 1 h later after dosing estazolam.The neurobehavioral ability index and balance function declined to the lowest level 3 h later after dosing estazolam.The neurobehavioral ability recovered partly 6 h later after dosing estazolam,and neurobehavioral ability recovered completely 10 h later.Conclusion Driving ability was impaired when estazolam concentration in blood is 20 ng/mL,and the neurobehavioral ability declined when estazolam concentration is 40 ng/mL in blood.The influence to hu-man in absorption process is greater than the metabolic process with the same estazolam concentration.

Key words: forensic toxicology, estazolam, neurobehavioral manifestations