法医学杂志

法医学杂志 ›› 2010, Vol. 0 ›› Issue (1): 56-58+6.

• 论文 • 上一篇    下一篇

胶束液相色谱法在体内毒物分析中的应用

程向炜;蒋文慧;褚建新;   

  1. 浙江警察学院;杭州市人民检察院;浙江省人民检察院;
  • 发布日期:2010-02-25 出版日期:2010-02-28

Micellar Liquid Chromatography and Its Application in Toxicological Analysis

CHENG XIANG-WEI1,JIANG WEN-HUI2,CHU JIAN-XIN3(1.ZHEJIANG POLICE COLLEGE,HANGZHOU 310053,CHINA;2.THE PEOPLE’S PROCURATORATE OF HANGZHOU,HANGZHOU 310014,CHINA;3.THE PEOPLE’S PROCURATORATE OF ZHEJIANG PROVINCE,HANGZHOU 310012,CHINA)   

  • Online:2010-02-25 Published:2010-02-28

摘要： 胶束液相色谱法是采用高于临界胶束浓度的表面活性剂溶液作为流动相的反相液相色谱方法。本文概述了胶束液相色谱法的基本原理和在理化分析方面的优势,介绍了其在毒品、巴比妥类镇静催眠药、苯二氮卓艹类催眠镇定药检验等方面的实际应用,认为胶束液相色谱法具有选择性高、适用范围广、生物样品处理简便等优点,可成为毒物分析的一种方法。

关键词: 法医毒理学, 色谱法, 液相, 综述[文献类型], 胶束

Abstract: Micellar liquid chromatography(MLC) is a reversed phase liquid chromatography with mobile phases containing surfactant above its critical micellar concentration(CMC).The basic mechanism and ad-vantages of MLC in physicochemical analysis were reviewed,and its applications in analysis of drugs,bar-biturates,benzodiazepines were chiefly introduced in this paper.MLC is a potential method to toxicological analysis due to strong selectivity,wide application scope and easy biological samples,etc.

Key words: forensic toxicology, chromatography, liquid, review[publication type], micellar