Evaluation of Visual Acuity of Ametropia with Visual Event-Related Potential Nogo-P3 Component

doi:10.12116/j.issn.1004-5619.2020.200406

Abstract

Abstract:

Objective To analyze the Nogo-P3 component of event-related potential （ERP） in the process of visual acuity processing， to provide electrophysiological evidence for objective evaluation of visual acuity. Methods Twenty-six subjects with no other ocular diseases except for ametropia were recruited， and all subjects had uncorrected visual acuity both eyes 1/10 （evaluated using Monoyer chart）. Block letter E with different visual angles and directions were used as graphic stimuli. The Go/Nogo paradigm was used for ERP studies. The visual angle of Go stimulation angle was 1°15′， Nogo stimuli were 1°15′， 55′， 24′ and 15′. The visual acuity test was performed on each of the two naked eyes separately in all subjects， and the characteristics of the Nogo-P3 component were analyzed. Results The latency of Nogo-P3 showed no difference between the stimuli of 1°15′ and 55′， and between Nogo stimulation angle 24′ and 15′. There was significant difference between Nogo stimulation angle 1°15′ and 24′， and between Nogo stimulation angle 1°15′ and 15′ （P<0.05）. There was significant difference between Nogo stimulation angle 55′ and 24′， and between Nogo stimulation angle 55′ and 15′ （P<0.05）. No significant differences were observed in the Nogo-P3 amplitude among Nogo stimulation. Conclusion In the Go/Nogo paradigm, Nogo-P3 can reflect the cognitive response of subjects to Nogo stimulation， which can be used for objective evaluation of visual acuity.

Key words: forensic medicine, event-related potential, vision, Nogo-P3, visual acuity, ametropia, latency, amplitude

CLC Number:

DF795.1

Fu-quan JIA, Xin-yuan ZHANG, Fang-liang LUO, Yan-he XIONG, Long-long CHENG, Ji-hui LIU. Evaluation of Visual Acuity of Ametropia with Visual Event-Related Potential Nogo-P3 Component[J]. Journal of Forensic Medicine, 2022, 38(3): 355-359.

Figures/Tables 5

Fig. 1 Basic stimulus pattern of ERP experimenton visual acuity

Fig. 2 Direction and visual angle of stimulation patterns

Fig. 3 Nogo-P3 waveforms

Fig. 4 Topographical maps within 300~600 ms after Nogo stimulation

Tab. 1 Latency and amplitude of Nogo-P3 in each module of Fz electrode （n=52，xˉ±s）

Nogo刺激视角	潜伏期/ms	波幅/μV
1°15′	495.78±67.93	10.65±3.25
55′	491.17±62.85	9.15±3.86
24′	441.31±54.67^1）2）	9.08±2.89
15′	438.10±52.42^1）2）	8.87±2.32

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