Progress in the Application of Magnetic Nanoparticles in Forensic Trace Analysis

doi:10.12116/j.issn.1004-5619.2022.320202

Abstract

Abstract:

Given the complexity of biological samples and the trace nature of target materials in forensic trace analysis, a simple and effective method is needed to obtain sufficient target materials from complex substrates. Magnetic nanoparticles （MNPs） have shown a wide range of application value in many research fields, such as biomedicine, drug delivery and separation, due to their unique superparamagnetic properties, stable physical and chemical properties, biocompatibility, small size, high specific surface area and other characteristics. To apply MNPs in the pretreatment of forensic materials, maximize the extraction rate of the target materials, and minimize interference factors to meet the requirements of trace analysis of the target materials, this paper reviews the application of MNPs in the fields of forensic toxicological analysis, environmental forensic science, trace evidence analysis and criminal investigation in recent years, and provides research ideas for the application of MNPs in forensic trace analysis.

Key words: forensic medicine, trace analysis, toxicological analysis, magnetic nanoparticle, review

CLC Number:

DF795.1

Zhong-ping CHENG, Yan-fei LIU, Xing-min XU, Yao-nan MO. Progress in the Application of Magnetic Nanoparticles in Forensic Trace Analysis[J]. Journal of Forensic Medicine, 2023, 39(2): 168-175.

References 60

1	JACINTO M J， SILVA V C， VALLADÃO D M S， et al. Biosynthesis of magnetic iron oxide nanoparticles： A review[J]. Biotechnol Lett，2021，43（1）：1-12. doi：10.1007/s10529-020-03047-0 .
2	YADWADE R， KIRTIWAR S， ANKAMWAR B. A review on green synthesis and applications of iron oxide nanoparticles[J]. J Nanosci Nanotechnol，2021，21（12）：5812-5834. doi：10.1166/jnn.2021.19285 .
3	DOWLATH M J H， MUSTHAFA S A， MOHAMED KHALITH S B， et al. Comparison of characteristics and biocompatibility of green synthesized iron oxide nanoparticles with chemical synthesized nanoparticles[J]. Environ Res，2021，201：111585. doi：10.1016/j.envres.2021.111585 .
4	XIE L， JIN W， CHEN H， et al. Superparamagnetic iron oxide nanoparticles for cancer diagnosis and therapy[J]. J Biomed Nanotechnol，2019，15（2）：215-416. doi：10.1166/jbn.2019.2678 .
5	刘小芳，于子辉，姜伯玮. 磁性纳米微球研究及其在法医学中的应用[C]//中国法医学理论与实践创新成果精选——全国第九次法医学术交流会论文集.北京，2013：167-169.
	LIU X F， YU Z H， JIANG B W. Research on magnetic nanospheres and their application in forensic medicine[C]// Selected innovative achievements of Chinese forensic medicine theory and practice -- Proceedings of the 9th National Forensic Academic Exchange Conference. Beijing，2013：167-169.
6	杨百全，李晨旭，鲍玉庆，等. 磁性纳米复合材料在法医学领域中的应用展望[J].刑事技术，2006（6）：13-15. doi：10.16467/j.1008-3650.2006.06.003 .
	YANG B Q， LI C X， BAO Y Q， et al. Complex magnetic nanomaterials used to biological separation[J]. Xingshi Jishu，2006（6）：13-15.
7	KABIR A， HOLNESS H， FURTON K G， et al. Recent advances in micro-sample preparation with forensic applications[J]. TrAC Trends Anal Chem，2013，45：264-279. doi：10.1016/j.trac.2012.11.013 .
8	CHEN D， ZHENG H B， HUANG Y Q， et al. Magnetic solid phase extraction coupled with desorption corona beam ionization-mass spectrometry for rapid analysis of antidepressants in human body fluids[J]. Analyst，2015，140（16）：5662-5670. doi：10.1039/c5an00992h .
9	BOOJARIA A， MASROURNIA M， GHORBANI H， et al. Silane modified magnetic nanoparticles as a novel adsorbent for determination of morphine at trace levels in human hair samples by high-performance liquid chromatography with diode array detection[J]. Forensic Sci Med Pathol，2015，11（4）：497-503. doi：10.1007/s12024-015-9702-8 .
10	SUPIYANI， AGUSNAR H， SUGITA P， et al. Preparation sodium silicate from rice husk to synthesize silica nanoparticles by sol-gel method for adsorption water in analysis of methamphetamine[J]. S Afr J Chem Eng，2022，40：80-86. doi：10.1016/j.sajce.2022.02.001 .
11	YILMAZ E， GARIPCAN B， PATRA H K， et al. Molecular imprinting applications in forensic science[J]. Sensors （Basel），2017，17（4）：691. doi：10.3390/s17040691 .
12	EL-BEQQALI A， ANDERSSON L I， JEPPSSON A D， et al. Molecularly imprinted polymer-sol-gel tablet toward micro-solid phase extraction： Ⅱ. Determination of amphetamine in human urine samples by liquid chromatography-tandem mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci，2017，1063：130-135. doi：10.1016/j.jchromb.2017.08.027 .
13	BATTAL D， AKGÖNÜLLÜ S， YALCIN M S， et al. Molecularly imprinted polymer based quartz crystal microbalance sensor system for sensitive and label-free detection of synthetic cannabinoids in urine[J]. Biosens Bioelectron，2018，111：10-17. doi：10.1016/j.bios.2018.03.055 .
14	ZHANG S， CUI Y， SUN J， et al. Sensitive magnetic solid-phase microextraction based on oxide multi-walled carbon-nanotubes for the determination of methylamphetamine and ketamine in human urine and blood[J]. Anal Methods，2015，7（10）： 4209-4215. doi：10.1039/C5AY00592B .
15	United Nations Office on Drugs and Crime （UNODC）. Guidelines for the forensic analysis of drugs facilitating sexual assault and other criminal acts[K/OL]. （2012-01-06）[2021-12-15]. .
16	滕姣，陈学国，高原，等. 药毒物分析中磁性固相萃取技术的应用进展[J].分析测试技术与仪器，2019，25（4）：252-259. doi：10.16495/j.1006-3757.2019.04.007 .
	TENG J， CHEN X G， GAO Y， et al. Application of magnetic solid-phase extraction in toxicological analysis[J]. Fenxi Ceshi Jishu Yu Yiqi，2019，25（4）：252-259.
17	王泽岚，周艳芬，孟哲，等. 核壳聚苯胺选择性磁性固相萃取-高效液相色谱-质谱法测定牛奶中痕量磺胺类药物[J].分析化学，2019，47（1）：119-128. doi：10.19756/j.issn.0253-3820.181478 .
	WANG Z L， ZHOU Y F， MENG Z， et al. Determination of trace sulfonamides antibiotics in milk using polyaniline silicon magnetic composite selective magnetic solid phase extraction combined with high performance liquid chromatography-mass spectrometry[J]. Fenxi Huaxue，2019，47（1）：119-128.
18	叶学敏，董丹琪，邵华，等. Fe₃O₄@SiO₂@C₁₄mimBF₄磁性固相萃取技术用于水中磺胺类药物分析[J].浙江工业大学学报，2020，48（5）：514-519，556. doi：10.3969/j.issn.1006-4303.2020.05.009 .
	YE X M， DONG D Q， SHAO H， et al. Determination of sulfonamides in water by Fe₃O₄@SiO₂@C₁₄ mimBF₄-based magnetic mixed hemimicelles solid phase extraction method[J]. Zhejiang Gongye Daxue Xuebao，2020，48（5）：514-519，556.
19	冯祖飞，赵颖娟，昌征. 磁性修饰羟基化多壁碳纳米管萃取人血浆中马钱子生物碱的方法研究[J].分析试验室，2017，36（4）：379-383. doi：10.13595/j.cnki.issn 1000-0720.2017.0079 .
	FENG Z F， ZHAO Y J， CHANG Z. Study on extraction of Nux-vomica alkaloids from the human plasm by the magnetic modified hydroxylated multi-walled carbon nanotubes[J]. Fenxi Shiyanshi，2017，36（4）：379-383.
20	CASTELLANOS D， ELLYN KOSOY J， DIAZ AYLLON K， et al. Presence of alcohol and drugs in hispanic versus non-hispanic youth suicide victims in Miami-dade County， Florida[J]. J Immigr Minor Health，2016，18（5）：1024-1031. doi：10.1007/s10903-016-0418-y .
21	DULKADIR Z， CHATURVEDI A K， CRAFT K J， et al. Tricyclic antidepressants found in pilots fatally injured in civil aviation accidents[J]. J Forensic Sci，2017，62（1）：164-168. doi：10.1111/1556-4029.13257 .
22	PELLETTI G， VERSTRAETE A G， REYNS T， et al. Prevalence of therapeutic drugs in blood of drivers involved in traffic crashes in the area of Bologna， Italy[J]. Forensic Sci Int，2019，302：109914. doi：10.1016/j.forsciint.2019.109914 .
23	FARNOUDIYAN-HABIBI A， MASSOUMI B， JAY-MAND M. A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples[J]. Spectrochim Acta A Mol Biomol Spectrosc，2016，168：235-243. doi：10.1016/j.saa.2016.06.013 .
24	BENFIELD P， HEEL R C， LEWIS S P. Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties， and therapeutic efficacy in depressive illness[J]. Drugs，1986，32（6）：481-508. doi：10.2165/00003495-198632060-00002 .
25	BARATI A， KAZEMI E， DADFARNIA S， et al. Synthesis/characterization of molecular imprinted polymer based on magnetic chitosan/graphene oxide for selective separation/preconcentration of fluoxetine from environmental and biological samples[J]. J Ind Eng Chem，2017，46：212-221. doi：10.1016/j.jiec.2016.10.033 .
26	陈建虎，徐文涛，高元，等. 磁性纳米材料固相萃取与GC/MS联用检测尿中安眠药残留[J].刑事技术，2014（4）：3-6. doi：10.16467/j.1008-3650.2014.04.005 .
	CHEN J H， XU W T， GAO Y， et al. Determination of hypnotics in urine by solid-phase extraction GC/MS[J]. Xingshi Jishu，2014（4）：3-6.
27	DANN A B， HONTELA A. Triclosan： Environmental exposure， toxicity and mechanisms of action[J]. J Appl Toxicol，2011，31（4）：285-311. doi：10.1002/jat.1660 .
28	LU Y C， MAO J H， ZHANG W， et al. A novel strategy for selective removal and rapid collection of triclosan from aquatic environment using magnetic molecularly imprinted nano-polymers[J]. Chemosphere，2020，238：124640. doi：10.1016/j.chemosphere.2019.124640 .
29	GAO D W， WEN Z D. Phthalate esters in the environment： A critical review of their occurrence， biodegradation， and removal during wastewater treatment processes[J]. Sci Total Environ，2016，541：986-1001. doi：10.1016/j.scitotenv.2015.09.148 .
30	GUO L， MA X， XIE X， et al. Preparation of dual-dummy-template molecularly imprinted polymers coated magnetic graphene oxide for separation and enrichment of phthalate esters in water[J]. Chem Eng J，2019，361：245-255. doi：10.1016/j.cej.2018.12.076 .
31	俞发荣，李登楼. 有机磷农药对人类健康的影响及农药残留检测方法研究进展[J].生态科学，2015，34（3）：197-203. doi：10.14108/j.cnki.1008-8873.2015.03.031 .
	YU F R， LI D L. A review on effect of organophosphorus pesticide on human health and the detection method of pesticide residue[J]. Shengtai Kexue，2015，34（3）：197-203.
32	张呈祥，侯明，鲍海咏，等. 急性有机磷农药中毒的相关进展[J].青海师范大学学报（自然科学版），2012，28（1）：54-61. doi：10.16229/j.cnki.issn1001-7542.2012.01.009 .
	ZHANG C X， HOU M， BAO H Y， et al. Interrelated progress of acute organophosphorus pesticide poisoning[J]. Qinghai Shifan Daxue Xuebao （Natural science），2012，28（1）：54-61.
33	胡晓，张敏. 有机磷农药对土壤微生物群落的影响[J].西南农业学报，2008，21（2）：384-389. doi：10.16213/j.cnki.scjas.2008.02.011 .
	HU X， ZHANG M. Effects of organophosphate pesticide on soil microbial community[J]. Xinan Nong-ye Xuebao，2008，21（2）：384-389.
34	洪亚军，冯承莲，徐祖信，等. 重金属对水生生物的毒性效应机制研究进展[J].环境工程，2019，37（11）：1-9. doi：10.13205/j.hjgc.201911001 .
	HONG Y J， FENG C L， XU Z X， et al. Advances on ecotoxicity effects of heavy metals to aquatic organisms and the mechanisms[J]. Huanjing Gongcheng，2019，37（11）：1-9.
35	LIANG Q， GENG J， LUO H， et al. Fast and selective removal of Cr（Ⅵ） from aqueous solutions by a novel magnetic Cr（Ⅵ） ion-imprinted polymer[J]. J Mol Liq，2017，248：767-774. doi：10.1016/j.molliq.2017.10.114 .
36	ZHONG D， ZHANG Y， WANG L， et al. Mechanistic insights into adsorption and reduction of hexavalent chromium from water using magnetic biochar composite： Key roles of Fe₃O₄ and persistent free radicals[J]. Environ Pollut，2018，243（Pt B）：1302-1309. doi：10.1016/j.envpol.2018.08.093 .
37	SHENG J， WANG L， DENG L， et al. MOF-templated fabrication of hollow Co₄N@N-doped carbon porous nanocages with superior catalytic activi-ty[J]. ACS Appl Mater Interfaces，2018，10（8）：7191-7200. doi：10.1021/acsami.8b00573 .
38	ZHOU T， LIANG Q， ZHOU X， et al. Enhanced removal of toxic hexavalent chromium from aqueous solution by magnetic Zr-MOF@polypyrrole： Performance and mechanism[J]. Environ Sci Pollut Res Int，2021，28（11）：13084-13096. doi：10.1007/s11356-021-12341-x .
39	LI P， YANG X， MIAO H， et al. Simultaneous determination of 19 triazine pesticides and degradation products in processed cereal samples from Chinese total diet study by isotope dilution-high performance liquid chromatography-linear ion trap mass spectrometry[J]. Anal Chim Acta，2013，781：63-71. doi：10.1016/j.aca.2013.04.027 .
40	ZHOU L， SU P， DENG Y， et al. Self-assembled magnetic nanoparticle supported zeolitic imidazolate framework-8： An efficient adsorbent for the enrichment of triazine herbicides from fruit， vegetables， and water[J]. J Sep Sci，2017，40（4）：909-918. doi：10.1002/jssc.201601089 .
41	周恋. 功能化磁性MOFs复合材料在有机农药残留萃取中的应用研究[D].北京：北京化工大学，2017.
	ZHOU L. Application of functional magnetic metal organic framework composites in the extraction of organic pesticide residues[D]. Beijing： Beijing University of Chemical Technology，2017.
42	姚伟宣，应剑波，张素玲，等. Fe₃O₄纳米粒子修饰多壁碳纳米管的制备及在水和蜂蜜样品中痕量菊酯类农药分析中的应用[J].色谱，2015，33（4）：342-347. doi：10.3724/SP.J.1123.2014.11029 .
	YAO W X， YING J B， ZHANG S L， et al. Preparation of multi-walled carbon nanotubes decorated with Fe₃O₄ nanoparticles for determination of trace pyrethroid pesticides in water and honey samples[J]. Sepu，2015，33（4）：342-347.
43	张凌怡，张润生，高方园，等. C₁₈修饰的磁性纳米材料用于不同性质农药的固相萃取理论研究与应用[J].分析试验室，2014，33（9）：1024-1029. doi：10.13595/j.cnki.issn1000-0720.2014.0242 .
	ZHANG L Y， ZHANG R S， GAO F Y， et al. Theory and application of solid-phase extraction based on octadecyl-functionalized magnetic nanoparticles for the determination of pesticides in aqueous samples[J]. Fenxi Shiyanshi，2014，33（9）：1024-1029.
44	BERENSMEIER S. Magnetic particles for the separation and purification of nucleic acids[J]. Appl Microbiol Biotechnol，2006，73（3）：495-504. doi：10.1007/s00253-006-0675-0 .
45	RITTICH B， SPANOVÁ A. SPE and purification of DNA using magnetic particles[J]. J Sep Sci，2013，36（15）：2472-2485. doi：10.1002/jssc.201300331 .
46	MA J， SHI H， ZHANG M， et al. A homogeneous， anti-dsDNA antibody-based assay for multicolor detection of cancer stem cell transcription factors[J]. Anal Chim Acta，2018，1029：72-77. doi：10.1016/j.aca.2018.04.060 .
47	曹佳利. 磁性纳米材料的制备及其在蛋白质分离分析上的应用[D].天津：南开大学，2014.
	CAO J L. Synthesis of magnetic nanomaterial and its application on separation and analysis of proteins[D]. Tianjin： Nankai University，2014.
48	MENG J， WANG Y， ZHOU Y， et al. A com-posite consisting of a deep eutectic solvent and dispersed magnetic metal-organic framework （type UiO-66-NH₂） for solid-phase extraction of RNA[J]. Mikrochim Acta，2019，187（1）：58. doi：10.1007/s00604-019-4040-2 .
49	ZANDIEH M， LIU J. Spherical nucleic acid mediated functionalization of polydopamine-coated na-noparticles for selective DNA extraction and detection[J]. Bioconjug Chem，2021，32（4）：801-809. doi：10.1021/acs.bioconjchem.1c00078 .
50	ZHANG M， LI L， LI B， et al. Adsorption of DNA by using polydopamine modified magnetic na-noparticles based on solid-phase extraction[J]. Anal Biochem，2019，579：9-17. doi：10.1016/j.ab.2019.05.004 .
51	程昉，冯前程，何炜，等. 一种用于抗体快速分离的嗜硫纳米粒子的制备及表征[J].分析化学，2018，46（12）：1953-1960. doi：10.11895/j.issn.0253-3820.181530 .
	CHENG F， FENG Q C， HE W， et al. Preparation and characterization of PEGylated thiophilic na-noparticles for rapid antibody separation[J]. Fenxi Huaxue，2018，46（12）：1953-1960.
52	许炎，陈荣华，徐庆文，等. 不同个体来源的混合精子细胞分离技术的研究[Z/OL]. （2020-01-01）[2021-12-15]. .
	XU Y， CHEN R H， XU Q W， et al. Study of hybrid spermatid cell separation techniques from different individual sources[Z/OL]. （2020-01-01）[2021-12-15]. .
53	王文静，孙宏浩，郭惠玲. 用于分离纯化组氨酸标签蛋白质的磁性复合纳米材料的制备[J].应用化工，2019，48（2）：294-297. doi：10.16581/j.cnki.issn1671-3206.2019.02.007 .
	WANG W J， SUN H H， GUO H L. Preparation of magnetic composite nanomaterials for separating and purifing histidine-tagged proteins[J]. Yingyong Huagong，2019，48（2）：294-297.
54	陈炯，冯巍，詹飞. hLCN6单克隆抗体偶联免疫磁珠用于混合细胞中精子的分离与法医学鉴定[J].生物工程学报，2019，35（1）：150-158. doi：10.13345/j.cjb.180075 .
	CHEN J， FENG W， ZHAN F. Separation and forensic identification of sperm from cell mixtures using anti-hLCN6 monoclonal antibody coupled magnetic beads[J]. Shengwu Gongcheng Xuebao，2019，35（1）：150-158.
55	周小凤. 纳米材料在潜在指印显现中的应用研究[D].重庆：西南政法大学，2013.
	ZHOU X F. Application of nanoparticles in latent fingermark detection[D]. Chongqing： Southwest University of Political Science and Law，2013.
56	GOESMANN H， FELDMANN C. Nanoparticulate functional materials[J]. Angew Chem Int Ed Engl，2010，49（8）：1362-1395. doi：10.1002/anie.200903053 .
57	ALGARRA M， RADOTIĆ K， KALAUZI A， et al. Fingerprint detection and using intercalated CdSe nanoparticles on non-porous surfaces[J]. Anal Chim Acta，2014，812：228-235. doi：10.1016/j.aca.2014.01.015 .
58	刘嘉扬，刘威岑，张赛，等. Fe₃O₄@Tb-BTC的制备及其在潜指印显现中的应用[J].刑事技术，2021，46（6）：559-565. doi：10.16467/j.1008-3650.2021.0108 .
	LIU J Y， LIU W C， ZHANG S， et al. Fe₃O₄@Tb-BTC： Preparation and applicability for latent fingerprint development[J]. Xingshi Jishu，2021，46（6）：559-565.
59	李菲，吴昊宬，李一峻，等. 功能化磁性纳米材料在样品前处理中的应用研究进展[J].色谱，2020，38（1）：2-13. doi：10.3724/SP.J.1123.2019.06034 .
	LI F， WU H C， LI Y J， et al. Progress in application of functionalized magnetic nanomaterials for sample pretreatment[J]. Sepu，2020，38（1）：2-13.
60	KÖSE K， KEHRIBAR D Y， UZUN L. Molecularly imprinted polymers in toxicology： A literature survey for the last 5 years[J]. Environ Sci Pollut Res Int，2021，28（27）：35437-35471. doi：10.1007/s11356-021-14510-4 .

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