Journal of Forensic Medicine ›› 2021, Vol. 37 ›› Issue (6): 914-918.DOI: 10.12116/j.issn.1004-5619.2020.500806
Received:2020-08-25
Online:2021-12-25
Published:2021-12-28
CLC Number:
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URL: http://www.fyxzz.cn/EN/10.12116/j.issn.1004-5619.2020.500806
| 检测区域 | 引物（5′→3′） | mtDNA位置 |
|---|---|---|
| HVR-I | F：GGGGAAGCAGATTTGGGTAC | 16033-16569 |
| R： CATCGTGATGTCTTATTTAAGGGGA | ||
| HVR-Ⅱ | F：GATCACAGGTCTATCACCCTATTA | 1-774 |
| R：CATTGCTGCGTGCTTGAT |
Tab. 1 Amplification primers of mtDNA HVR-Ⅰ and HVR-Ⅱ
| 检测区域 | 引物（5′→3′） | mtDNA位置 |
|---|---|---|
| HVR-I | F：GGGGAAGCAGATTTGGGTAC | 16033-16569 |
| R： CATCGTGATGTCTTATTTAAGGGGA | ||
| HVR-Ⅱ | F：GATCACAGGTCTATCACCCTATTA | 1-774 |
| R：CATTGCTGCGTGCTTGAT |
| STR基因座 | 引物（5′→3′） | 在2号染色体上的位置 |
|---|---|---|
| D2S144 | F：TCTCCCTGACAGACTCTGCG | 25500833-25501006 |
| R：GCTGCATAGGCCGTACTGAG | ||
| D2S2223 | F：CACTGCGCCTAGCCTC | 26559144-26559325 |
| R：GGCGATTTATGAATAATCCTGC | ||
| D2S174 | F：AGGCTGAATCCCACCTCC | 26839873-26840075 |
| R：TTAGAGCACACATGGTCACTCC | ||
| D2S223 | F：CTGTTTTTGTGGTAAGCACC | 28337888-28338131 |
| R：TTTTTAGGTTCACCCAAATATG | ||
| D2S358 | F：TCGTGGTCTCAAGCATC | 68897544-68897710 |
| R：GGAAGGACTTGGCAGG | ||
| 2-69446 | F：AGGCTTCTGTGTGCGTAGTC | 69446395-69446723 |
| R：ATAGTGCCTGGCTCATGGTG | ||
| D2S2152 | F：TTTGGGGTACAACTGATCC | 69715260-69715391 |
| R：CTCTAAACGTGTGTGTGTGG | ||
| D2S2115 | F：CCCCATGCCCATGTAACA | 70351703-70351792 |
| R：AAGCGCCTACTAGATGCCAT | ||
| ABCB11-AC1 | F：ATTTCCCTTCAAACCTCTC | 168813096-168813291 |
| R：TACTATAGGATGAGAGGCAG | ||
| ABCB11-AC2 | F：CATTTCACTATCATGCTGTC | 168947593-168947763 |
| R：CAATTTAAACTTGTGCTGGA | ||
| ABCB11-AC3 | F：GTGAGTCTCCATTATTCATTTCT | 169408755-169408981 |
| R：GATATGCATCTCCTAATTTGCCA | ||
| ABCB11-CA1 | F：GGCCTCAAACTCAGCAGGAT | 170222311-170222424 |
| R：TGGCTGAGATGCATATGAGAAAT | ||
| ABCB11-CA2 | F：GGGCAATCTTGAGCAAGTCTCT | 170255379-170255615 |
| R：GTTCATGTGGGTTTGACTTTCACA | ||
| D2S2284 | F：CAAAGCTGAGAAATGGGTATC | 171493405-171493570 |
| R：CATTGCACTGGAACTATCTTTTA | ||
| D2S2194 | F：CCCCCAAGTTTTTTCAAG | 171681418-171681559 |
| R：CTGTTTTATTTAGCCTACACTCG |
Tab. 2 PCR primer sequences of additional autosomal STR loci on chromosome 2
| STR基因座 | 引物（5′→3′） | 在2号染色体上的位置 |
|---|---|---|
| D2S144 | F：TCTCCCTGACAGACTCTGCG | 25500833-25501006 |
| R：GCTGCATAGGCCGTACTGAG | ||
| D2S2223 | F：CACTGCGCCTAGCCTC | 26559144-26559325 |
| R：GGCGATTTATGAATAATCCTGC | ||
| D2S174 | F：AGGCTGAATCCCACCTCC | 26839873-26840075 |
| R：TTAGAGCACACATGGTCACTCC | ||
| D2S223 | F：CTGTTTTTGTGGTAAGCACC | 28337888-28338131 |
| R：TTTTTAGGTTCACCCAAATATG | ||
| D2S358 | F：TCGTGGTCTCAAGCATC | 68897544-68897710 |
| R：GGAAGGACTTGGCAGG | ||
| 2-69446 | F：AGGCTTCTGTGTGCGTAGTC | 69446395-69446723 |
| R：ATAGTGCCTGGCTCATGGTG | ||
| D2S2152 | F：TTTGGGGTACAACTGATCC | 69715260-69715391 |
| R：CTCTAAACGTGTGTGTGTGG | ||
| D2S2115 | F：CCCCATGCCCATGTAACA | 70351703-70351792 |
| R：AAGCGCCTACTAGATGCCAT | ||
| ABCB11-AC1 | F：ATTTCCCTTCAAACCTCTC | 168813096-168813291 |
| R：TACTATAGGATGAGAGGCAG | ||
| ABCB11-AC2 | F：CATTTCACTATCATGCTGTC | 168947593-168947763 |
| R：CAATTTAAACTTGTGCTGGA | ||
| ABCB11-AC3 | F：GTGAGTCTCCATTATTCATTTCT | 169408755-169408981 |
| R：GATATGCATCTCCTAATTTGCCA | ||
| ABCB11-CA1 | F：GGCCTCAAACTCAGCAGGAT | 170222311-170222424 |
| R：TGGCTGAGATGCATATGAGAAAT | ||
| ABCB11-CA2 | F：GGGCAATCTTGAGCAAGTCTCT | 170255379-170255615 |
| R：GTTCATGTGGGTTTGACTTTCACA | ||
| D2S2284 | F：CAAAGCTGAGAAATGGGTATC | 171493405-171493570 |
| R：CATTGCACTGGAACTATCTTTTA | ||
| D2S2194 | F：CCCCCAAGTTTTTTCAAG | 171681418-171681559 |
| R：CTGTTTTATTTAGCCTACACTCG |
| 基因座 | 法定父亲 | 孩子 | 母亲 |
|---|---|---|---|
| D3S1358 | 14/16 | 16/17 | 15/17 |
| D1S1656 | 15/16 | 16/17 | 13/17 |
| D6S1043 | 12/18 | 12/21 | 12/21 |
| D13S317 | 9 | 9/10 | 9/10 |
| Penta E | 10/16 | 16 | 16/23 |
| D16S539 | 9/12 | 9/12 | 9/11 |
| D18S51 | 13/24 | 15/24 | 14/15 |
| D2S13381） | 17/23 | 17/23 | 19 |
| CSF1PO | 11/12 | 12 | 10/12 |
| Penta D | 9 | 9 | 9 |
| TH01 | 7/9 | 7/8 | 7/8 |
| vWA | 14/20 | 14/19 | 17/19 |
| D21S11 | 31.2/32.2 | 29/31.2 | 29/32.2 |
| D7S820 | 8 | 8 | 8 |
| D5S818 | 12/13 | 10/13 | 10 |
| TPOX1） | 8 | 8 | 9 |
| D8S1179 | 10/14 | 10/14 | 10/14 |
| D12S391 | 15/20 | 20 | 20 |
| D19S433 | 15.2 | 13/15.2 | 13/16.2 |
| FGA | 23/24 | 20/24 | 19/20 |
| D4S2366 | 10/11 | 11/12 | 12/13 |
| D6S477 | 14 | 14/17 | 17 |
| D22GATA198B05 | 17/18 | 18/19 | 19/22 |
| D15S659 | 12/17 | 10/17 | 10/13 |
| D8S1132 | 20/21 | 19/20 | 19/20 |
| D3S3045 | 11/13 | 9/13 | 9 |
| D14S608 | 7 | 7/11 | 11/12 |
| D17S1290 | 13/16 | 16 | 11/16 |
| D3S1744 | 17/18 | 17/18 | 14/17 |
| D2S4411） | 10/15 | 10/15 | 12/14 |
| D18S535 | 11/13 | 11/14 | 10/14 |
| D13S325 | 22/23 | 22/23 | 22 |
| D7S1517 | 22/24 | 22/27 | 23/27 |
| D10S1435 | 11/15 | 11/12 | 12 |
| D11S2368 | 18 | 18/20 | 19/20 |
| D19S2531） | 12 | 12/14 | 13/15 |
| D7S3048 | 21/24 | 22/24 | 18/22 |
| D10S1248 | 14 | 12/14 | 12/13 |
| D5S2500 | 13/14 | 11/13 | 11 |
Tab. 3 Genotype of the 39 autosomal STR lociin the alleged father， child and mother
| 基因座 | 法定父亲 | 孩子 | 母亲 |
|---|---|---|---|
| D3S1358 | 14/16 | 16/17 | 15/17 |
| D1S1656 | 15/16 | 16/17 | 13/17 |
| D6S1043 | 12/18 | 12/21 | 12/21 |
| D13S317 | 9 | 9/10 | 9/10 |
| Penta E | 10/16 | 16 | 16/23 |
| D16S539 | 9/12 | 9/12 | 9/11 |
| D18S51 | 13/24 | 15/24 | 14/15 |
| D2S13381） | 17/23 | 17/23 | 19 |
| CSF1PO | 11/12 | 12 | 10/12 |
| Penta D | 9 | 9 | 9 |
| TH01 | 7/9 | 7/8 | 7/8 |
| vWA | 14/20 | 14/19 | 17/19 |
| D21S11 | 31.2/32.2 | 29/31.2 | 29/32.2 |
| D7S820 | 8 | 8 | 8 |
| D5S818 | 12/13 | 10/13 | 10 |
| TPOX1） | 8 | 8 | 9 |
| D8S1179 | 10/14 | 10/14 | 10/14 |
| D12S391 | 15/20 | 20 | 20 |
| D19S433 | 15.2 | 13/15.2 | 13/16.2 |
| FGA | 23/24 | 20/24 | 19/20 |
| D4S2366 | 10/11 | 11/12 | 12/13 |
| D6S477 | 14 | 14/17 | 17 |
| D22GATA198B05 | 17/18 | 18/19 | 19/22 |
| D15S659 | 12/17 | 10/17 | 10/13 |
| D8S1132 | 20/21 | 19/20 | 19/20 |
| D3S3045 | 11/13 | 9/13 | 9 |
| D14S608 | 7 | 7/11 | 11/12 |
| D17S1290 | 13/16 | 16 | 11/16 |
| D3S1744 | 17/18 | 17/18 | 14/17 |
| D2S4411） | 10/15 | 10/15 | 12/14 |
| D18S535 | 11/13 | 11/14 | 10/14 |
| D13S325 | 22/23 | 22/23 | 22 |
| D7S1517 | 22/24 | 22/27 | 23/27 |
| D10S1435 | 11/15 | 11/12 | 12 |
| D11S2368 | 18 | 18/20 | 19/20 |
| D19S2531） | 12 | 12/14 | 13/15 |
| D7S3048 | 21/24 | 22/24 | 18/22 |
| D10S1248 | 14 | 12/14 | 12/13 |
| D5S2500 | 13/14 | 11/13 | 11 |
Fig. 1 Gene mapping of the 3 STR loci on chromosome 2
| 基因座 | 孩子 | 母亲 |
|---|---|---|
| DXS6795 | 10 | 10/13 |
| DXS9902 | 10 | 10/12 |
| DXS8378 | 11 | 10/11 |
| HPRTB | 13 | 13 |
| GATA165B12 | 10 | 10 |
| DXS7132 | 15 | 15 |
| DXS7424 | 16 | 15/16 |
| DXS6807 | 14 | 14/15 |
| DXS6803 | 12.3 | 12.3/13.3 |
| GATA172D05 | 10 | 6/10 |
| DXS6800 | 16 | 16 |
| DXS10134 | 36 | 35/36 |
| GATA31E08 | 9 | 9/11 |
| DXS10159 | 27 | 25/27 |
| DXS6789 | 21 | 16/21 |
| DXS6810 | 18 | 18 |
Tab. 4 Genotype of X-STR loci ofthe child and mother
| 基因座 | 孩子 | 母亲 |
|---|---|---|
| DXS6795 | 10 | 10/13 |
| DXS9902 | 10 | 10/12 |
| DXS8378 | 11 | 10/11 |
| HPRTB | 13 | 13 |
| GATA165B12 | 10 | 10 |
| DXS7132 | 15 | 15 |
| DXS7424 | 16 | 15/16 |
| DXS6807 | 14 | 14/15 |
| DXS6803 | 12.3 | 12.3/13.3 |
| GATA172D05 | 10 | 6/10 |
| DXS6800 | 16 | 16 |
| DXS10134 | 36 | 35/36 |
| GATA31E08 | 9 | 9/11 |
| DXS10159 | 27 | 25/27 |
| DXS6789 | 21 | 16/21 |
| DXS6810 | 18 | 18 |
| mtDNA碱基位置 | 孩子 | 母亲 |
|---|---|---|
| 73 | 73G | 73G |
| 248 | 248del | 248del |
| 263 | 263G | 263G |
| Nt303-315 HVRⅡ C-stretch | 309.2C/309.3C | 309.2C/309.3C |
| Nt514-524（CA）3~7 | （CA）4 | （CA）4 |
| 16182 | 16182C | 16182C |
| 16183 | 16183C | 16183C |
| Nt16184-16193 HVRⅠ C-stretch | 10C | 10C |
| 16303 | 16303A | 16303A |
| 16304 | 16304C | 16304C |
| 16519 | 16519C | 16519C |
Tab. 5 Matching analysis between mtDNA hypervariableregions of the child and mother and mtDNA rCRS
| mtDNA碱基位置 | 孩子 | 母亲 |
|---|---|---|
| 73 | 73G | 73G |
| 248 | 248del | 248del |
| 263 | 263G | 263G |
| Nt303-315 HVRⅡ C-stretch | 309.2C/309.3C | 309.2C/309.3C |
| Nt514-524（CA）3~7 | （CA）4 | （CA）4 |
| 16182 | 16182C | 16182C |
| 16183 | 16183C | 16183C |
| Nt16184-16193 HVRⅠ C-stretch | 10C | 10C |
| 16303 | 16303A | 16303A |
| 16304 | 16304C | 16304C |
| 16519 | 16519C | 16519C |
| STR基因座 | 法定父亲 | 孩子 | 母亲 | |||
|---|---|---|---|---|---|---|
| 等位基因1 | 等位基因2 | 等位基因1 | 等位基因2 | 等位基因1 | 等位基因2 | |
| D2S144 | 178.29 | 184.05 | 178.34 | 184.09 | 172.48 | 187.77 |
| D2S2223 | 190.83 | 192.75 | 190.81 | 192.73 | 181.36 | 185.17 |
| D2S174 | 203.27 | 207.05 | 203.30 | 207.04 | 197.67 | 201.43 |
| D2S223 | 234.03 | 234.03 | 233.98 | 233.98 | 225.31 | 235.95 |
| D2S358 | 162.50 | 166.54 | 162.63 | 166.57 | 154.51 | 166.58 |
| 2-69446 | 327.39 | 348.15 | 327.20 | 348.09 | 348.15 | 353.56 |
| D2S2152 | 131.21 | 133.35 | 131.13 | 133.35 | 131.06 | 137.55 |
| D2S2115 | 67.81 | 76.36 | 67.80 | 75.41 | 68.41 | 83.60 |
| ABCB11-AC1 | 195.26 | 197.23 | 195.03 | 197.05 | 187.55 | 192.09 |
| ABCB11-AC2 | 169.41 | 169.41 | 169.46 | 169.46 | 163.83 | 165.85 |
| ABCB11-AC3 | 216.76 | 216.76 | 216.77 | 216.77 | 222.65 | 222.65 |
| ABCB11-CA1 | 102.41 | 102.41 | 102.68 | 102.68 | 106.76 | 106.76 |
| ABCB11-CA2 | 211.75 | 229.52 | 211.60 | 229.57 | 209.61 | 227.71 |
| D2S2284 | 166.57 | 166.57 | 166.53 | 166.53 | 162.67 | 162.67 |
| D2S2194 | 134.35 | 138.69 | 134.42 | 138.69 | 131.79 | 143.98 |
Tab. 6 Analysis results of additional STR loci onchromosome 2 of the alleged father， child and mother
| STR基因座 | 法定父亲 | 孩子 | 母亲 | |||
|---|---|---|---|---|---|---|
| 等位基因1 | 等位基因2 | 等位基因1 | 等位基因2 | 等位基因1 | 等位基因2 | |
| D2S144 | 178.29 | 184.05 | 178.34 | 184.09 | 172.48 | 187.77 |
| D2S2223 | 190.83 | 192.75 | 190.81 | 192.73 | 181.36 | 185.17 |
| D2S174 | 203.27 | 207.05 | 203.30 | 207.04 | 197.67 | 201.43 |
| D2S223 | 234.03 | 234.03 | 233.98 | 233.98 | 225.31 | 235.95 |
| D2S358 | 162.50 | 166.54 | 162.63 | 166.57 | 154.51 | 166.58 |
| 2-69446 | 327.39 | 348.15 | 327.20 | 348.09 | 348.15 | 353.56 |
| D2S2152 | 131.21 | 133.35 | 131.13 | 133.35 | 131.06 | 137.55 |
| D2S2115 | 67.81 | 76.36 | 67.80 | 75.41 | 68.41 | 83.60 |
| ABCB11-AC1 | 195.26 | 197.23 | 195.03 | 197.05 | 187.55 | 192.09 |
| ABCB11-AC2 | 169.41 | 169.41 | 169.46 | 169.46 | 163.83 | 165.85 |
| ABCB11-AC3 | 216.76 | 216.76 | 216.77 | 216.77 | 222.65 | 222.65 |
| ABCB11-CA1 | 102.41 | 102.41 | 102.68 | 102.68 | 106.76 | 106.76 |
| ABCB11-CA2 | 211.75 | 229.52 | 211.60 | 229.57 | 209.61 | 227.71 |
| D2S2284 | 166.57 | 166.57 | 166.53 | 166.53 | 162.67 | 162.67 |
| D2S2194 | 134.35 | 138.69 | 134.42 | 138.69 | 131.79 | 143.98 |
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