Abstract: Diagnosis of nervous system injury is one of the most difficult issues in medical-legal practice. Nowadays, the activation of NF-κB has been studied by many researchers in order to find objective evidence and indicators to calculate the injury time and to diagnose the severity of brain injury for forensic practice. It was reviewed that the advances and problems of NF-κB and its correlation with nervous system injury and diseases, such as cerebral ischemia, traumatic brain injury, Alzheimer′s disease and amyotrophic lateral sclerosis.

Key words: forensic medicine, NF-kappa B, review [publication type], trauma, nervous system, nervous system diseases