Distribution of Aconitum Alkaloids in the Corpse Died of Acute Aconite Intoxication

Abstract

Abstract: Objective To investigate the distribution of aconite alkaloids in biological fluids and tissues in the corpse died of acute aconite intoxication and to provide information for sample selection and result evaluation in forensic identification.Methods The content of aconite alkaloids in biological fluids and tissues were determined by liquid chromatography-tandem mass spectrometry.Results The content of aconite displayed in decending order of urine,bile,gastric content,heart blood,pancreas,heart,intestine,liver,kidney,stomach,lung,gallbladder and spleen,with no aconite detected in the brain.Conclusion It was indicated that urine,bile and blood are the best specimens for the determination of aconite in body of the acute aconite intoxication.

Key words: forensic toxicology, aconitum alkaloids, LC-MS/MS, tissue distribution

LIU WEI;SHEN MIN;QIN ZHI-QIANG(.DEPARTMENT OF FORENSIC MEDICINE;SHANGHAI MEDICAL COLLEGE;FUDAN UNIVERSITY;SHANGHAI 000;CHINA;.SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE;INSTITUTE OF FORENSIC SCIENCE;MINISTRY OF JUSTICE;P.R.CHINA;SHANGHAI 000. Distribution of Aconitum Alkaloids in the Corpse Died of Acute Aconite Intoxication[J]. , 2009, 0(3): 176-178.

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Distribution of Aconitum Alkaloids in the Corpse Died of Acute Aconite Intoxication

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