Abstract: Objective To reveal the genetic polymorphisms of four SNP loci （rs77434921, rs2076907, rs6283, rs1800762） in D5 gene of dopamine receptor （DRD5） in Northern Chinese Han population. Methods Four SNP loci of the DRD5 gene of 206 unrelated individuals in Northern Chinese Han population were separately amplified and sequenced by PCR technique and statistically analyzed by Haploview v4.1 software. Results In Northern Chinese Han population, the genotype frequency distribution of rs77434921, rs2076907, rs6283 and rs1800762 loci in the DRD5 gene were all in accordance with Hardy-Weinberg equilibrium. DP value was 0.145, 0.532, 0.602 and 0.159, while PE value was 0.004, 0.079, 0.196 and 0.007. A linkage disequilibrium among these four SNP loci was also demonstrated, which might infer five haplotypes. Conclusion rs2076907 and rs6283 loci of DRD5 gene in the Northern Chinese Han population have high genetic polymorphisms, which can be useful for forensic identification of individuals.

Key words: forensic genetics, polymorphism, genetic, receptors, dopamine D5, Han nationality