Abstract: Objective To determine the HLA-Cw allele and genotype frequencies from Xi'an Han population and obtain genetic data. Methods The results of HLA-Cw typing for 130 randomly selected from Xi'an Han population were obtained by using the PCR-Sequence Specific Oligonucleotide Probes (SSOP). Results In this investigation, 16 alleles were detected among 130 unrelated individuals with frequencies from 0.007 7 to 0.158 8 and HLA-Cw*01?03?07 were the most common HLA-Cw alleles. We have made a survey of HLA-Cw alleles frequencies in Xi'an Han Population, with blank frequency being lowered to 0.018 2. Conclusion The distribution of genotype frequencies met the law of Hardy-Weinberg equilibrium by Hi-square test. The frequency data can be used in forensic and paternity tests, transplant matching and anthropology.

Key words: HLA-Cw, PCR-SSOP, polymorphism, Xi'an Han population