Abstract: Objective To establish an inductively coupled plasma mass spectrometry(ICP-MS) method for determination of Cr, Cd, As, Tl and Pb in blood. Methods The samples were digested by microwave di- gestion instrument. ICP-MS was applied to determine Cr, Cd, As, Tl and Pb in blood by using 115In as an internal standard. Results The limits of detection were in the range of 0.000 01-0.002 49 μg/L. The accu- racy of the method ranged from 90.1% to 110.7% and the precision ranged from 4.0% to 7.9%. Conclusion The method is accurate and rapid with superior sensitivity and linear range. It could be used in the poisoning cases caused by Cr, Cd, As, Tl and Pb.

Key words: forensic toxicology, inductively coupled plasma mass spectrometry, blood, metals, heavy