Journal of Forensic Medicine

›› 2014, Vol. 30 ›› Issue (3): 169-171.DOI: 10.3969/j.issn.1004-5619.2014.03.003

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Expression of CaMKⅡδ in Cerebral Cortex Following Traumatic Brain Injury

PAN HONG1, ZHANG JING-JING1, XU DONG-DONG2, GU ZHEN-YONG1, TAO LU-YANG3, ZHANG MING-YANG1,3   

  1. （1. Department of Forensic Medicine, Medical College, Nantong University, Nantong 226001, China; 2. Department of Forensic Medicine, North Sichuan Medical College, Nanchong 640073, China; 3. Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China）
  • Online:2014-06-25 Published:2014-06-28

Abstract: Objective To observe the time-course expression of calcium-calmodulin dependent protein kinaseⅡδ（CaMKⅡδ） in cerebral cortex after traumatic brain injury（TBI）. Methods The TBI rat model was established. The expression of CaMKⅡδ in cerebral cortex around injured area was tested by Western blotting and immunohistochemical staining. Results Western blotting revealed expression of CaMKⅡδ in normal rat brain cortex. It gradually increased after TBI, peaked after 3 days, and then returned to normal level. The result of immunohistochemical staining was consistent with that of Western blotting. Conclusion The expression of CaMKⅡδ around injured area after TBI increased initially and then decreased. It could be used as a new indicator for wound age determination following TBI.

Key words: forensic pathology, brain injuries, calcium-calmodulin dependent protein kinase Ⅱ, rats

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