Research Progress on Molecular Markers Related to Unexplained Sudden Cardiac Death and Its Forensic Application

doi:10.12116/j.issn.1004-5619.2020.400507

Abstract

Abstract:

Routine pathological examination of unexplained sudden cardiac death （USCD） lacks significant morphological characteristics. In the field of forensic medicine, molecular biology methods have been used to find the cause of death by detecting genes and research related to the mechanism of sudden cardiac death has been carried out. From the molecular pathology point of view, the application of multiple levels of biomarkers to resolve the causes of USCD has already shown potential and provides an important path for forensic identification of USCD. This article reviews the latest research progress on USCD-related genes, RNA, proteins and USCD, and summarizes forensic application.

Key words: forensic pathology, sudden cardiac death, molecular biomarker, review

CLC Number:

DF795.1

Xiang-wang HE, Lin-feng LI, Fu ZHANG, Li-bing YUN. Research Progress on Molecular Markers Related to Unexplained Sudden Cardiac Death and Its Forensic Application[J]. Journal of Forensic Medicine, 2021, 37(5): 687-693.

Figures/Tables 2

References 59

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疾病		相关基因	参考文献
离子通道疾病
	Brugada综合征	SCN5A， SCN10A， HEY2	[23-26]
	CPVT	RYR2，CASQ2，TRDN， CALM1，CALM2，CALM3，TECRL	[27-28]
	长Q-T间期综合征	KCNQ1，HERG， SCN5A， ANK2，KCNE1，KCNE2，KCNJ2，CACNA1C， CAV3，SCN4B， AKAP9，SNTA1，KCNJ5，CALM1，CALM2，CALM3，Triadin， KCNH2	[7，29-30]
心律失常性心肌病		DSC2，DSG2，DSP， LDB3，LMNA， MYBPC3，MYH7，PKP2，TNNI3，TNNT2，ACTC1，MYH6，MYL2，MYL3，TNNC1，TPM1，ABCC9，ACTN2，CALR3，CSRP3，DES， FKTN， GLA， JPH2，JUP， LAMP2，MYLK2，MYOZ2，NEXB， PLN， PRKAG2，RBM20，SGCD， TAZ， TCAP， TGFB3，TMEM43，TMPO， VCL	[1，31]
其他类型心律失常		AKAP9，ANK2，CACNA1C， CANB2，CASQ2，CAV3，GDP1L， HCN4，KCNE1，KCNE2，KCNE3，KCNJ2，SCN1B， SCN3B， SCN4B， SNTA1，MYL4，DSP， QIL1，FLNC	[1，14，32-33]

疾病		相关基因	参考文献
离子通道疾病
	Brugada综合征	SCN5A， SCN10A， HEY2	[23-26]
	CPVT	RYR2，CASQ2，TRDN， CALM1，CALM2，CALM3，TECRL	[27-28]
	长Q-T间期综合征	KCNQ1，HERG， SCN5A， ANK2，KCNE1，KCNE2，KCNJ2，CACNA1C， CAV3，SCN4B， AKAP9，SNTA1，KCNJ5，CALM1，CALM2，CALM3，Triadin， KCNH2	[7，29-30]
心律失常性心肌病		DSC2，DSG2，DSP， LDB3，LMNA， MYBPC3，MYH7，PKP2，TNNI3，TNNT2，ACTC1，MYH6，MYL2，MYL3，TNNC1，TPM1，ABCC9，ACTN2，CALR3，CSRP3，DES， FKTN， GLA， JPH2，JUP， LAMP2，MYLK2，MYOZ2，NEXB， PLN， PRKAG2，RBM20，SGCD， TAZ， TCAP， TGFB3，TMEM43，TMPO， VCL	[1，31]
其他类型心律失常		AKAP9，ANK2，CACNA1C， CANB2，CASQ2，CAV3，GDP1L， HCN4，KCNE1，KCNE2，KCNE3，KCNJ2，SCN1B， SCN3B， SCN4B， SNTA1，MYL4，DSP， QIL1，FLNC	[1，14，32-33]

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