法医学杂志 ›› 2021, Vol. 37 ›› Issue (1): 69-76.DOI: 10.12116/j.issn.1004-5619.2020.400328

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冠状病毒感染性疾病尸体检验相关病原学检测回顾与展望

王韵怡1 ,周南1 ,乐嘉诚1 ,张凯1 ,赵乾皓1 ,郑大1 ,胡丙杰2 ,成建定1   

  1. 1. 中山大学中山医学院法医学系,广东 广州 510080;2. 广州医科大学病理学教研室,广东 广州 511436
  • 收稿日期:2020-03-31 出版日期:2021-02-25 发布日期:2021-02-25
  • 通讯作者: 胡丙杰,男,教授,主任法医师,主要从事法医病理学和法医学史研究;E-mail:hubingjie@126.com 成建定,男,教授,主任法医师,主要从事病毒性心肌炎及不明原因猝死的法医病理学研究;E-mail:chengjd@mail.sysu.edu.cn
  • 作者简介:王韵怡(1995—),女,硕士研究生,主要从事猝死的法医病理学研究;E-mail:710963059@qq.com
  • 基金资助:
    国家重点研发计划资助项目(2017YFC0803502);国家自然科学基金资助项目(81920108021);广州市科技计划资助项 目(2019030015)

Review and Prospects of Pathogen Detection Related to Autopsy of Coronavirus Infectious Diseases

WANG Yun-yi1 , ZHOU Nan1 , YUE Jia-cheng1 , ZHANG Kai1 , ZHAO Qian-hao1 , ZHENG Da1 , HU Bingjie2 , CHENG Jian-ding1   

  1. 1. Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; 2. Department of Pathology, Guangzhou Medical University, Guangzhou 511436, China
  • Received:2020-03-31 Online:2021-02-25 Published:2021-02-25

摘要: 冠状病毒曾经给世界带来两次严重的人类间大流行,包括严重急性呼吸综合征(severe acute re? spiratory syndrome,SARS)和中东呼吸综合征(Middle East respiratory syndrome,MERS),2019年岁末新型 冠状病毒肺炎(coronavirus disease 2019,COVID-19)再次引发了全球性的重大公共卫生事件。由于新型冠 状病毒传染性较强,相关死亡病例的解剖工作难以广泛开展。本文对既往冠状病毒感染性疾病尸体检验 相关的病原学检测情况进行回顾,介绍了临床上正在开展的新型冠状病毒的检测手段,旨在为开展COVID-19尸体检验相关的病原学检测和研究提供借鉴和参考。

关键词: 法医病理学, 冠状病毒, 新型冠状病毒肺炎, 严重急性呼吸综合征, 中东呼吸综合征, 尸体解剖, 病 原学检测, 综述

Abstract: In the past, coronavirus caused two serious human-to-human pandemics in the world, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome(MERS). In late 2019, coronavirus disease 2019 (COVID- 19) caused another major global public health event. Due to the strong infectivity of novel coronavirus, it is difficult to carry out the autopsy of related death cases widely. This paper reviews the previous status of the pathogen detection related to the autopsy of coronavirus infection diseases, and introduces the ongoing detection methods of novel coronavirus in clinical practice, in order to provide reference for the pathogen detection and study related to autopsy of COVID-19.

Key words: forensic pathology, coronavirus, coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome, Middle East respiratory syndrome, autopsy, pathogen detection, review

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