法医学杂志

法医学杂志 ›› 2014, Vol. 30 ›› Issue (6): 466-463.DOI: 10.3969/j.issn.1004-5619.2014.06.016

• 综述 • 上一篇    下一篇

颅脑损伤修复机制与载脂蛋白E基因多态性的研究进展

尤  玥1，2，李如波1   

  1. （1. 中国医科大学法医学院法医病理学教研室，辽宁 沈阳 110001； 2. 中国医科大学第一临床学院，辽宁 沈阳 110001）
  • 发布日期:2014-12-25 出版日期:2014-12-28
  • 通讯作者: 李如波，男，教授，博士，主要从事法医病理学教学、研究及鉴定工作；E-mail：rbli@mail.cmu.edu.cn
  • 作者简介:尤玥（1990—），女，河北乐亭人，主要从事临床医学、法医病理学研究；E-mail：the.way.u.are@163.com
  • 基金资助:

    辽宁省教育厅科学研究一般项目（L2013317）；辽宁省自然科学基金资助项目（2014021027）

Progress of the Recovery Mechanism of Brain Injury Associated with the Gene Polymorphism of Apolipoproteins E

YOU YUE1,2, LI RU-BO1   

  1. （1. Teaching and Research Office of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China; 2. School of the First Clinical College, China Medical University, Shenyang 110001, China）
  • Online:2014-12-25 Published:2014-12-28

被引次数

6

摘要： 颅脑损伤是一种由暴力作用于头颅引起的损伤，由致伤外力作用于头部所导致的颅骨、脑膜、脑血管和脑组织的机械形变。载脂蛋白E（apolipoproteins E，ApoE）是载脂蛋白的一个重要类型，参与机体脂质代谢及胆固醇平衡的调节。近年来发现，ApoE的基因多态性与多种疾病相关，其免疫反应性与脑损伤时间有关联，神经系统的正常生长和损伤后修复都具有一定规律性。本文对ApoE的生物学特性、脑损伤后的作用机制以及在法医学中的应用前景进行综述，希望为脑创伤时间推断及其相关实验研究提供新的思路。

关键词: 法医病理学, 颅脑损伤, 综述[文献类型], 多态现象, 遗传, 载脂蛋白E类

Abstract: Brain injury is a kind of wound by violence on head, which is a mechanical distortion of skull, meninx, cerebral vascular and brain tissue due to outside force acting on head. Apolipoproteins E （ApoE） is a major kind of apolipoproteins, participating in the metabolism of lipid and regulating balance of cholesterol. Some recent investigations show that gene polymorphism of ApoE is associated with various kinds of diseases. Also its immunoreactivity is changed regularly with brain injury. In addition, ApoE has remarkable effect in neurological normal growth and reparative process after brain injury. This article reviews the biological characteristics and mechanism of ApoE in the repair of brain injury and application prospect in forensic medicine, which may be able to provide new ideas for estimation of the brain injury time and related experimental research.

Key words: forensic pathology, craniocerebral trauma, review [publication type], polymorphism, genetic;apolipoproteins E

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