法医学杂志

法医学杂志 ›› 2009, Vol. 0 ›› Issue (3): 200-203+.

• 论文 • 上一篇    下一篇

氯胺酮成瘾机制的研究进展

刘伟丽;卞士中;顾振纶;蒋小岗;秦正红;   

  1. 苏州大学医学部法医学教研室;苏州中药研究所;苏州大学衰老与神经疾病实验室;
  • 发布日期:2009-06-25 出版日期:2009-06-28

Advances in Research of Ketamine Addiction Mechanism

LIU WEI-LI1,BIAN SHI-ZHONG1,GU ZHEN-LUN2,3,JIANG XIAO-GANG2,3,QIN ZHENG-HONG2,3(1.DEPARTMENT OF FORENSIC MEDICINE,MEDICAL COLLEGE OF SOOCHOW UNIVERSITY,SUZHOU 215123,CHINA;2.SUZHOU INSTITUTE OF CHINESE MATERIA MEDICA,SUZHOU 215006,CHINA;3.LABORATORY OF AG   

  • Online:2009-06-25 Published:2009-06-28

摘要： 氯胺酮为苯环己哌啶(PCP)衍生物,是非竞争性N-甲基-D-天门冬氨酸(NMDA)受体拮抗剂。除作为临床上常用的静脉麻醉药外,氯胺酮还具有一定的致幻作用和成瘾性,非法滥用氯胺酮的人数呈现快速增长趋势。本文根据氯胺酮的药理及毒理学特性与目前公认的药物成瘾机制,从与药物成瘾机制有关的强化效应和奖赏系统、解剖结构、相关受体及个体差异等方面,对氯胺酮成瘾的可能机制作一综述。

关键词: 法医毒理学, 氯胺酮, 综述[文献类型], 物质相关性障碍

Abstract: Ketamine is a phencyclidine derivative acting primarily as a noncompetitive antagonist of Nmethyl-D-aspartate(NMDA) excitatory glutamate receptors.As a common intravenous anaesthetic in clinic,it is also increasingly abused because of its hallucination and addiction effects.Based on the pharmacological and toxicologic characteristics of ketamine and the acknowledged addiction mechanism of other abused drugs,this article reviews the possible addiction mechanism of the ketamine in the aspects of its enhanced effects and reward systems,the anatomic structures,the related receptors and the individual differences.

Key words: forensic toxicology, ketamine, review[publication type], substance-related disorders