法医学杂志

法医学杂志 ›› 2009, Vol. 25 ›› Issue (1): 37-39.

• 论文 • 上一篇    下一篇

血液中Cr、Cd、As、Tl和Pb的电感耦合等离子体质谱分析

马栋;沈敏;卓先义;严慧;向平;刘伟;   

  1. 复旦大学上海医学院法医学系;司法部司法鉴定科学技术研究所上海市法医学重点实验室;
  • 发布日期:2009-02-25 出版日期:2009-02-28

Determination of Cr, Cd, As, Tl and Pb in Blood by Inductively Coupled Plasma Mass Spectrometry

MA DONG1,2, SHEN MIN2, ZHUO XIAN-YI2, YAN HUI1, XIANG PING2, LIU WEI2 (1. DEPARTMENT OF FORENSIC MEDICINE, SHANGHAI MEDICAL COLLEGE, FUDAN UNIVERSITY, SHANGHAI 200032, CHINA; 2. SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE, INSTITUTE OF FORENSIC SCIENCE,   

  • Online:2009-02-25 Published:2009-02-28

摘要： 目的建立血液中Cr、Cd、As、Tl和Pb的电感耦合等离子体质谱(ICP-MS)分析方法。方法血液采用微波消解仪进行处理,以115In元素作内标,使用ICP-MS方法对血液中Cr、Cd、As、Tl和Pb进行分析。结果方法检出限为0.00001～0.00249μg/L,准确度为90.1%～110.7%,精密度为4.0%～7.9%。结论建立的方法准确、快速、线性范围宽、灵敏度高,适用于Cr、Cd、As、Tl和Pb中毒案件的检测。

关键词: 法医毒理学, 电感耦合等离子体质谱法, 血液, 金属, 重

Abstract: Objective To establish an inductively coupled plasma mass spectrometry(ICP-MS) method for determination of Cr, Cd, As, Tl and Pb in blood. Methods The samples were digested by microwave di- gestion instrument. ICP-MS was applied to determine Cr, Cd, As, Tl and Pb in blood by using 115In as an internal standard. Results The limits of detection were in the range of 0.000 01-0.002 49 μg/L. The accu- racy of the method ranged from 90.1% to 110.7% and the precision ranged from 4.0% to 7.9%. Conclusion The method is accurate and rapid with superior sensitivity and linear range. It could be used in the poisoning cases caused by Cr, Cd, As, Tl and Pb.

Key words: forensic toxicology, inductively coupled plasma mass spectrometry, blood, metals, heavy