法医学杂志

法医学杂志 ›› 2016, Vol. 32 ›› Issue (4): 290-295.DOI: 10.3969/j.issn.1004-5619.2016.04.013

• 综述 • 上一篇    下一篇

滥用药物体内代谢的研究进展

丁碧粉1，2，邵  雷2，张润生3，梁  晨3，张玉荣3   

  1. （1. 上海师范大学生命与环境科学学院，上海 200234； 2. 中国医药工业研究总院上海医药工业研究院 创新药物与制药工艺国家重点实验室，上海 200040； 3. 上海市公安局物证鉴定中心 上海市现场物证重点实验室，上海 200083）
  • 发布日期:2016-08-25 出版日期:2016-08-28
  • 通讯作者: 张玉荣，男，主任法医师，主要从事毒品、毒物分析；E-mail：yr_zhang@126.com
  • 作者简介:丁碧粉（1987—），女，硕士研究生，主要从事微生物药物的制备与分析；E-mail：dingbifenjgh@163.com

Research Progress on Abused Drugs Metabolic in vivo

DING BI-FEN1,2, SHAO LEI2, ZHANG RUN-SHENG3, LIANG CHEN3, ZHANG YU-RONG3   

  1. （1. College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China; 2. State Key Laboratory of Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China; 3. Shanghai Key laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China）
  • Online:2016-08-25 Published:2016-08-28

被引次数

4

摘要： 摘  要： 毒品在体内尿苷二磷酸葡醛酸转移酶、细胞色素P450、羧酸酯酶、磺基转移酶、丁酰胆碱酯酶、儿茶酚-O-甲基转移酶和吗啡6-脱氢酶等代谢酶催化下，发生葡萄糖醛酸化、水解、氧化、磺酸化等多种反应，生成有活性或者无活性的代谢产物，然后经尿液、胆汁或者其他途径排出体外。不同毒品的代谢途径不同。本文介绍了近年来吗啡类、苯丙胺类、氯胺酮、大麻类和可卡因等毒品在人和动物体内的代谢研究，综述了这些毒品体内代谢的代谢部位、代谢酶、代谢产物及其生理活性的研究进展。

关键词: 法医毒物学, 毒品, 综述[文献类型], 代谢

Abstract: Abstract： Under the catalysis of a variety of metabolic enzymes in vivo, such as UDP-glucuronyl transferases, cytochrome P450, carboxylesterase, sulfotransferase, butyrylcholinesterase, catechol-O-methyl transferase and 6-morphine dehydrogenase, the drugs perform glucuronidation, hydrolysis, oxidation, sulfonation and other reactions, then translate into active or inactive metabolites, which are excreted through urination, bile or the other pathways at last. Different drugs own their different metabolic pathways. This paper introduces the studies about the metabolism of drugs in human and animal in recent years, such as morphine-like drugs, amphetamine, ketamine, cannabis and cocaine, and reviews the research progress about the sites of metabolism, metabolic enzymes, metabolites and physiological activity of those drugs metabolic in vivo.

Key words: forensic toxicology, drugs, review [publication type], metabolism

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