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法医学杂志 2017, Vol. 33 Issue (6) :599-603    DOI: 10.3969/j.issn.1004-5619.2017.06.006
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甲基苯丙胺滥用与司来吉兰服用的区分:尿液中甲基苯丙胺和苯丙胺的手性分析
向平,卜俊,乔正,卓先义,吴何坚,沈敏
(司法鉴定科学研究院 上海市法医学重点实验室 上海市司法鉴定专业技术服务平台,上海 200063)
Identification of Methamphetamine Abuse and Selegiline Use: Chiral Analysis of Methamphetamine and Amphetamine in Urine
XIANG PING, BU JUN, QIAO ZHENG, ZHUO XIAN-YI, WU HE-JIAN, SHEN MIN
(Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China)

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摘要 目的 考察司来吉兰及其代谢物在尿液中的含量变化,并结合实际案例探讨手性分析区分甲基苯丙胺滥用与司来吉兰服用的可行性。 方法 采用CHIROBIOTICTM V2手性液相色谱柱对尿液样品进行手性分离和液相色谱-串联质谱(LC-MS/MS)法测定,并对司来吉兰服药志愿者尿样、疑服用司来吉兰的涉毒人员尿样进行甲基苯丙胺和苯丙胺的手性分析。 结果 服用5 mg司来吉兰后,尿液中司来吉兰的检出时限仅为7 h。尿液中R(-)-甲基苯丙胺和R(-)-苯丙胺约在7 h质量浓度最高,分别为0.86 μg/mL和0.18 μg/mL,并在80 h和168 h后无法检出。应用该方法成功分析了疑服用司来吉兰的涉毒人员尿液中甲基苯丙胺和苯丙胺的来源。 结论 甲基苯丙胺和苯丙胺的手性分析以及司来吉兰代谢物检测可区分甲基苯丙胺滥用与司来吉兰服用。
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向平
卜俊
乔正
关键词法医毒理学   甲基苯丙胺   苯丙胺   司来吉兰   手性分析   液相色谱-串联质谱   尿     
Abstract: Objective To study the content variation of selegiline and its metabolites in urine, and based on actual cases, to explore the feasibility for the identification of methamphetamine abuse and selegiline use by chiral analysis. Methods The urine samples were tested by chiral separation and LC-MS/MS method using CHIROBIOTICTM V2 chiral liquid chromatography column. The chiral analysis of methamphetamine and amphetamine were performed on the urine samples from volunteers of selegiline use and drug addicts whom suspected taking selegiline. Results After 5 mg oral administration, the positive test time of selegiline in urine was less than 7 h. The mass concentrations of R(-)-methamphetamine and R(-)-amphetamine in urine peaked at 7 h which were 0.86 ?滋g/mL and 0.18 ?滋g/mL and couldn’t be detected after 80 h and 168 h, respectively. The sources of methamphetamine and amphetamine in the urine from the drug addicts whom suspected taking selegiline were analysed successfully by present method. Conclusion The chiral analysis of methamphetamine and amphetamine, and the determination of selegiline’s metabolites can be used to distinguish methamphetamine abuse from selegiline use.
Keywordsforensic toxicology   methamphetamine   amphetamine   selegiline   chiral analysis   LC-MS/MS   urine     
Fund:

“十三五”国家重点研发计划资助项目(2016YFC0800 704);上海市科委资助项目(15dz1207500);上海市法医学重点实验室资助项目(17DZ2273200);上海市司法鉴定专业技术服务平台资助项目(16DZ2290900)

Corresponding Authors: 沈敏,女,硕士,研究员,主要从事法医毒物学研究;E-mail:shenm@ssfjd.cn   
About author: 向平(1968—),女,博士,研究员,主要从事法医毒物学研究;E-mail:xiangp@ssfjd.cn 通信作者:
引用本文:   
向平, 卜俊, 乔正, 等.甲基苯丙胺滥用与司来吉兰服用的区分:尿液中甲基苯丙胺和苯丙胺的手性分析[J]  法医学杂志, 2017,33(6): 599-603
XIANG PING, BU JUN, QIAO ZHENG, DENG , ET AL..Identification of Methamphetamine Abuse and Selegiline Use: Chiral Analysis of Methamphetamine and Amphetamine in Urine[J]  , 2017,33(6): 599-603
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