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法医学杂志 2018, Vol. 34 Issue (5) :542-548    DOI: 10.12116/j.issn.1004-5619.2018.05.021
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16S rRNA基因测序在法医学中的研究进展
宋国庆1,2,3,曹  禹2,3,李  辉2,3,马  克2,3,赵雪莹2,3,邹凯南2,3,周怀谷1,2,3
1. 复旦大学基础医学院法医学系,上海 200032; 2. 上海市公安局物证鉴定中心 法医物证学现场应用技术公安部重点实验室 上海市现场物证重点实验室,上海 200083; 3. 上海市刑事科学技术研究院,上海 200083
Progress in the 16S rRNA Gene Sequencing in Forensic Science
SONG Guo-qing1,2,3, CAO Yu2,3, LI Hui2,3, MA Ke2,3, ZhAO Xue-ying2,3, ZOU Kai-nan2,3, ZHOU Huai-gu1,2,3
1. Department of Forensic Medicine, School of Basic Medical Science, Fudan University, Shanghai 200032, China; 2. Shanghai Key Laboratory of Crime Scene Evidence, Key Laboratory of Forensic Evidence and Science Technology, Ministry of Public Security, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China; 3. Shanghai Research Institute of Criminal Science and Technology, Shanghai 200083, China

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摘要 法医微生物是目前法医学研究的前沿热点之一。16S rRNA基因由于其保守性与特异性并存的特点,是法医学鉴定的理想标记。伴随着高通量测序技术的快速发展,对微生物的研究已逐步应用于环境、医疗等多个领域。在法医学领域,以16S rRNA基因测序为代表的法医微生物研究成果也逐步应用于法医学实践中的生物检材鉴定、个体识别、死亡时间推断、地域推断等方面,为案件的侦查提供线索,为传统方法作为补充和辅助。本文阐述了16S rRNA基因测序应用于法医学领域的研究方法和相关测序技术,综述了其在法医学领域的研究进展,探讨了16S rRNA在法医学中的应用价值和潜力。
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宋国庆
曹禹
李辉
关键词法医遗传学   RNA   核糖体   16S   遗传学   微生物   综述     
Abstract: Forensic microorganism is one of the hotspots of forensic science research. Due to its conservatism and specificity, the 16S rRNA gene is found to be an ideal marker for forensic identification. With the rapid development of high throughput sequencing technology, the research on microorganisms has been gradually applied to many fields such as environment and health care. In the field of forensic science, the results of forensic microbiology research, represented by 16S rRNA gene sequencing, are also gradually applied to forensic practice, such as biological samples identification, individual identification, postmortem interval estimation, and regional inference, which not only provide clues for the investigation of cases but also complement and assist traditional methods. This paper describes the research methods and related sequencing technologies of 16S rRNA gene sequencing, summarizes its research progress, and discusses the application value and potential of 16S rRNA in forensic science.
Keywordsforensic genetics   RNA, ribosomal, 16S   genetics, microbial   review     
Corresponding Authors: 周怀谷,男,博士,主任法医师,主要从事法医DNA分析技术的应用和研究;E-mail:hgzhou803@hotmail.com   
About author: 宋国庆(1991—),男,硕士研究生,主要从事法医遗传学研究;E-mail:16211010073@fudan.edu.cn
引用本文:   
宋国庆,曹禹,李辉,等.16S rRNA基因测序在法医学中的研究进展[J]  法医学杂志, 2018,34(5): 542-548
SONG Guo-qing, CAO Yu, LI Hui,et al..Progress in the 16S rRNA Gene Sequencing in Forensic Science[J]  法医学杂志, 2018,34(5): 542-548
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