Abstract: Objective To investigate the effect and expression of the vascular cell adhesion molecule-1（VCAM-1） in organs of rats died of anaphylactic shock. Methods The models of anaphylactic shock in rats were made and the immunohistochemisty of SABC was used to detect as follows： （1） The expression of VCAM-1 in rat lung, heart, brain, kidney, liver, spleen, stomach and intestine. （2） VCAM-1 levels in lungs at 10 min, 30 min after the allergic shock, and the time of death. （3） VCAM-1 levels in lungs of rats after the intervention of anti-VCAM-1. Results After the death, the expression VCAM-1 in lungs increased significantly relative to the control group and followed the extension of shock. In the rats which were injected with the anti-VCAM-1, the expression of VCAM-1 in lungs reduced. Conclusion （1） The expression of VCAM-1 shows difference in the various organs of rats after anaphylactic shock. The change of VCAM-1 is the most obvious in lungs and would increase followed the extension of anaphylactic shock. （2） After the anaphylactic shock, anti-VCAM-1 can inhibit the expression of VCAM-1 in rat lung.

Key words: forensic pathology, anaphylaxis, vascular cell adhesion molecule-1, rats