Journal of Forensic Medicine

›› 2011, Vol. 27 ›› Issue (6): 401-404.DOI: 10.3969/j.issn.1004-5619.2011.06.001

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The Expression of GABAA Receptor α1 and GABAB Receptor 1 in Medulla Oblongata Solitary Nucleus and Ambiguous Nucleus in the Cases of Tramadol Intoxication

ZHANG SHU1, GUAN DA-WEI1, WANG LING1,2, WANG HUA-XIN1,3, ZHANG GUO-HUA1, ZHAO RUI1, FAN YAN-YAN1   

  1. （1. Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China; 2. Department of Emergency, General Hospital of Shenyang Military Area Command, Shenyang 110001, China; 3. Department of Pathology and Forensic Medicine, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China）
  • Online:2011-12-25 Published:2011-12-28

Abstract: Objective To observe the expression of GABAA receptor α1 （GABAAα1） and GABAB receptor 1 （GABAB1） in human medulla oblongata solitary nucleus and ambiguous nucleus due to tramadol-induced death. Methods GABAAα1 and GABAB1 were detected by immunohistochemical SP method in tramadol-induced death group and control group. All results were evaluated by images analysis system. Results Low expression of GABAAα1 and GABAB1 were detected in solitary nucleus and ambiguous nucleus in the control brain tissue. In cases of tramadol-induced death, the expression of GABAAα1 and GABAB1 significantly increased. Conclusion The mechanism of tramadol intoxication death could be caused by respiratory depression induced by over-expression of GABAAα1 and GABAB1 in medulla oblongata solitary nucleus and ambiguous nucleus.

Key words: forensic pathology, poisoning, tramadol, solitary nucleus, ambiguous nucleus, receptors, GABA

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