Abstract: A method was described for the determination of fenfluramine by GC/MS in blood, urine, liver, lung, kidney and heart tissues. After liquid-liquid extraction of fenfluramine in the specimens obtained from autopsy, the samples were qualitatively identified by GC/MS, and quantitatively determined by GC/NPD. 4-phenyl butylamine was used as internal standard. The concentrations of fenfluramine in blood, urine and liver were 7.8μg/ml, 64.2 μg/ml and 31.3 μg/g respectively. The findings of autopsy and the results of toxicological analysis were also discussed.

Key words: fenfluramine, liquid-liquid extraction, blood, urine, GC/MS, GC/NPD