Abstract: Objective To study the distribution and metabolism of methamphetamine in the hair of guinea pig.Methods Determination of methamphetamine and its metabolite amphetamine in hair was performed by GC/MS and GC/NPD. Concentration-time course of methamphetamine and amphetamine in hair of guinea were recorded. Relationship between hair color, administrated dose and drug concentration in hair were also discussed. Results The concentration of amphetamine is higher than the concentration of methamphetamine in the hair of guinea administrated a single dose or seven doses of methamphetamine. The concentration of methamphetamine and amphetamine were significantly related with administration dose and the incorporation rate into white and brown hair is much poorer than that of black hair. Conclution Administration methods, dose and the color of hair affect the concentration of methamphetamine and amphetamine.

Key words: distribution, metabolism, methamphetamine, amphetamine, hair, guinea pig