Abstract: Objective To investigate the expressions of calpain1 and calpain2 during the skin incised wound healing in mice.Methods Expression of calpain1 and calpain2 was evaluated by immunohistochemical method.Results Both calpain1 and calpain2 were expressed in the skin cells in the control groups.The calpain1 positive cells were remarkably increased and reached the maximal level in day 1 after skin incised wound,decreased after day 3,markedly increased again in day 5,and then gradually decreased from day 7 to 14;the calpain2 positive cells were significantly increased in day 1 and decreased to the minimum in day 3,markedly increased again in day 5,and then gradually decreased from day 7 to 10.Conclusion The changes of calpain1 and calpain2 expressions appear to be bimodal after incised wound of skin in mice.

Key words: calpain, skin incised wound, injury age, forensic pathology