Abstract: Objective To observe the changes of expression of phosphorylation c-Jun NH2-terminal kinase(p-JNK) during the skin burned wound healing in patients and discuss the molecular mechanism of burned wound healing. Methods The staining intensity and distribution of p-JNK were detected by immunohistochemistry and routine histology in burned skin samples of 12 patients and normal skin samples of 12 control subjects. Results In normal skin,the positive signals of p-JNK were mostly localized in basal layer cells of the epidermis,with a positive rate of (8.8±1.3)%. In the burned group,the positive signals of p-JNK were mainly localized in the epidermal cells and some inflammatory cells,with a significantly higher positive rate of (31.2±3.3)% than the normal group(P<0.01). Conclusion The changes of p-JNK expression after skin burned might correlate with wound healing.

Key words: forensic pathology, burn injury, JNK mitogen-activated protein kinases, wound healing