Journal of Forensic Medicine

›› 2015, Vol. 31 ›› Issue (3): 185-187.DOI: 10.3969/j.issn.1004-5619.2015.03.003

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Effect of Heroin on DLG4 Expression in Hippocampus, Amygdala and Frontal Cortex of Rats

LUO LIANG-MING1,2, GONG QUN3, LIU JIAN-FENG1, ZHAO MING-QUAN1, CHEN DONG-DONG4, XIE YAO-YAO5, ZHU HUA2   

  1. （1. Institute of Criminal Science and Technology, Wenzhou Public Security Bureau, Wenzhou 325000, China; 2. Department of Forensic Medicine, Wenzhou Medical University, Wenzhou 325035, China; 3. Criminal Police Corps, Zhejiang Province Public Security Bureau, Hangzhou 310009, China; 4. Criminal Investigation Brigade of the Development Zone, Wenzhou Public Security Bureau, Wenzhou 325000, China; 5. Longwan District Branch of Criminal Investigation Brigade, Wenzhou Public Security Bureau, Wenzhou 325000, China）
  • Online:2015-06-25 Published:2015-06-28

Abstract: Objective To observe the expression of discs large homolog 4 （DLG4） protein in hippocampus, amygdala and frontal cortex of rats and evaluate postsynaptic density in heroin dependence. Methods The rat heroin dependent model was established by increasing intraperitoneal injection of heroin. DLG4 proteins in hippocampus, amygdala and frontal cortex of heroin dependent 9, 18, 36 days rats were detected with immunohistochemical staining and compared with that in the control group. Results DLG4 proteins in hippocampus, amygdala and frontal cortex were gradually reduced with extension of heroin dependent time. Conclusion Heroin dependence can affect postsynaptic density of hippocampus, amygdala and frontal cortex. The changes become more apparent with extension of heroin dependence time.

Key words: forensic pathology, heroin dependence, hippocampus, amygdala, frontal cortex, DLG4, rats

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