Journal of Forensic Medicine

›› 2016, Vol. 32 ›› Issue (2): 94-96.DOI: 10.3969/j.issn.1004-5619.2016.02.004

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Expression of PTEN in Myocardial Tissue in Coronary Heart Disease

LI XUE-RONG1, HE YONG1, LEI YU-JIA1, QIN XI-HE1, WEI QING-TAO1, PAN XIN-MIN2, LI LI-JUAN1, ZHANG LIN1   

  1. （1. West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China; 2. School of Forensic Medicine, Henan University of Science and Technology, Luoyang 471003, China）
  • Online:2016-04-25 Published:2016-04-28

Abstract: Objective To observe the expression of phosphatase and tensin homology deleted on chromosome ten （PTEN） in myocardial tissue in patients with coronary heart disease, and explore the relevance between the expression of PTEN and the occurrence and development of coronary heart disease. Methods A total of 16 death cases with pathological diagnosis of coronary heart disease were collected as experimental group, and 19 cases without myocardial lesions were selected as control group. The expression of PTEN protein and its mRNA were detected by immunohistochemistry and real-time fluorescence quantitative PCR respectively. The correlation between the expression of PTEN and the pathogenesis of coronary heart disease was analyzed. Results The expression of PTEN protein in myocardium in cases with coronary heart disease was significantly lower compared with the control group （P<0.05）. There was no statistical difference of the expression of PTEN mRNA between experimental and control group （P>0.05）. Conclusion PTEN may be involved in the occurrence and development of coronary heart disease.

Key words: forensic pathology, coronary arteriosclerosis, myocardium, phosphatase and tensin homolog deleted on chromosome ten

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