法医学杂志

法医学杂志 ›› 2021, Vol. 37 ›› Issue (3): 388-395.DOI: 10.12116/j.issn.1004-5619.2019.491116

• 综 述 • 上一篇    下一篇

代谢组学在心脏性猝死鉴定中的应用前景及展望

谷祯， 牛佳佳， 安国帅， 杜秋香， 曹洁， 靳茜茜， 王英元， 孙俊红   

  1. 山西医科大学法医学院，山西 太原 030001
  • 发布日期:2021-06-25 出版日期:2021-06-28
  • 通讯作者: 孙俊红，男，博士，教授，主要从事损伤病理学和猝死病理学研究；E-mail：junhong.sun@sxmu.edu.cn 王英元，男，教授，博士研究生导师，主要从事法医病理学（损伤及死亡时间）研究；E-mail：wyy580218@163.com
  • 作者简介:谷祯（1995—），男，主要从事法医病理学研究；E-mail：840172682@qq.com
  • 基金资助:
    国家重点研发计划资助项目（2017YFC0803502）；山西省应用基础研究项目青年科技基金资助项目（201801D221264）

Application Prospects and Prospect of Metabolomics in the Identification of Sudden Cardiac Death

GU Zhen, NIU Jia-jia, AN Guo-shuai, DU Qiu-xiang, CAO Jie, JIN Qian-qian, WANG Ying-yuan, SUN Jun-hong   

  1. School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China
  • Online:2021-06-25 Published:2021-06-28

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摘要： 在猝死案例中，心脏性猝死的预防及猝死发生后死因鉴定一直是难点问题。因此，心脏性猝死的临床研究和法医病理学鉴定具有重要意义。近年来，代谢组学逐渐发展成为生命科学研究的热门领域，检测生物体液的“代谢指纹”可以为疾病早期诊断、潜在生物标志物的发掘等提供重要依据。本文就心脏性猝死的研究现状以及与心脏性猝死密切相关的心血管疾病代谢组学方面的研究做一综述，分析代谢组学在心脏性猝死鉴定中的应用前景。

关键词: 法医病理学, 代谢组学, 心脏性猝死, 综述

Abstract: In cases of sudden death, the prevention of sudden cardiac death and the analysis of the cause of death after sudden cardiac death have always been a difficult problem. Therefore, clinical research and forensic pathological identification of sudden cardiac death are of great significance. In recent years, metabolomics has gradually developed into a popular field of life science research. The detection of “metabolic fingerprints” of biological fluids can provide an important basis for early diagnosis of diseases and the discovery of potential biomarkers. This article reviews the current research status of sudden cardiac death and the research on metabolomics of cardiovascular diseases that is closely related to sudden cardiac death and analyzes the application prospects of metabolomics in the identification of the cause of sudden cardiac death.

Key words: forensic pathology, metabolomics, sudden cardiac death, review

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