法医学杂志

法医学杂志 ›› 2005, Vol. 0 ›› Issue (1): 55-57+6.

• 论文 • 上一篇    下一篇

维生素D受体基因多态性研究进展

徐波,王保捷   

  1. 中国医科大学法医学院,中国医科大学法医学院 辽宁沈阳110001 ,辽宁沈阳110001
  • 发布日期:2005-02-25 出版日期:2005-02-28

Advances in the Research of Vitamin D Receptor Gene

XU BO, WANG BAO-JIE (SCHOOL OF FORENSIC MEDICINE,CHINA MEDICAL UNIVERSITY, SHENYANG 110001,CHINA)   

  • Online:2005-02-25 Published:2005-02-28

被引次数

22

摘要： 维生素D受体(vitaminDreceptor,VDR)基因多态性可能与骨密度、骨质疏松、身高相关。本文作者就近年国内外所开展的VDR基因4个单核苷酸多态性(singlenucleotidepolymorphism,SNP)位点FokI、BsmI、ApaI、TaqI与骨密度、骨质疏松、身高关联性研究进行综述,发现各国的研究结果虽不尽相同,但VDR基因多态性在遗传学、临床内分泌代谢,尤其在法医学领域对身高的研究中,有重要的应用价值。

关键词: VDR基因, 多态性, 骨密度, 骨质疏松, 身高

Abstract: The polymorphism of vitamin D receptor (VDR) gene may be associated with bone density, osteoporosis and body height. In this review, the authors summarize the association of the four VDR single nucleotide polymorphisms (SNPs) loci FokI, BsmI, ApaI, TaqI with bone density, osteoporosis and body height reported at home and abroad in recent years. And find that though each country′s report may be different, it′s valuable in the field of genetics, clinical endocrinology and metabolism, especially in the research area of body height in Forensic Medicine.

Key words: VDR gene, polymorphism, bone density, osteoporosis, body height