法医学杂志

法医学杂志 ›› 2018, Vol. 34 ›› Issue (1): 73-78.DOI: 10.3969/j.issn.1004-5619.2018.01.014

• 综述 • 上一篇    下一篇

circRNA研究进展及其法医学应用展望

涂春艳，金恺迪，邵诚臣，刘宝年，张雅琪，谢建辉，沈忆文   

  1. 复旦大学基础医学院法医系，上海 200032
  • 发布日期:2018-02-25 出版日期:2018-02-28
  • 通讯作者: 沈忆文，女，博士，副教授，主要从事法医学教学、科研及鉴定；E-mail：shenyiwen@fudan.edu.cn
  • 作者简介:涂春艳（1991—），女，硕士研究生，主要从事法医病理学及法医临床学研究；E-mail：16211010074@fudan.edu.cn

Research Progress of CircRNA and Its Application Prospect in Forensic Medicine

TU Chun-yan, JIN Kai-di, SHAO Cheng-chen, LIU Bao-nian, ZHANG Ya-qi, XIE Jian-hui, SHEN Yi-wen   

  1. Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
  • Online:2018-02-25 Published:2018-02-28

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摘要： 环状RNA（circular RNA，circRNA）是一类通过首尾相连形成的非编码RNA，在组织细胞中表达丰富，具有组织表达特异性的特点，并且具有较高的稳定性。最近的研究表明，circRNA在疾病及发生发展中具有调控功能，可能应用于临床疾病诊断以及帮助阐明疾病发病机制。本文对circRNA的生物学特性、分析研究方法以及作为分子生物学标记在临床应用中的研究进展进行综述，并对其在法医学领域中的应用进行展望。

关键词: 法医遗传学, 环状RNA, 综述, 遗传标记, 生物学标记

Abstract: Circular RNA （circRNA） is a type of noncoding RNA with tissue specificity and high stability, which forms a closed continuous loop and is abundantly expressed in tissue cells. According to recent research, the regulatory function of circRNA elucidating in the occurrence and development of disease shows a potential for diagnosing clinical disease and revealing disease mechanism. This paper reviews the biological characteristics, analysis methods of circRNA and its research progress in clinical application as biomarker, and outlooks its application in the field of forensic medicine.

Key words: forensic genetics, circRNA, review, genetic markers, biological markers

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