法医学杂志

法医学杂志 ›› 2009, Vol. 25 ›› Issue (3): 172-175.

• 论文 • 上一篇    下一篇

氯胺酮致小鼠产生类精神分裂症的行为改变

刘伟丽;卞士中;顾振纶;蒋小岗;郭次仪;赵彦伯;   

  1. 苏州大学医学部法医学系;苏州中药研究所;苏州大学衰老与神经疾病实验室;昆山市公安局刑警大队法医室;
  • 发布日期:2009-06-25 出版日期:2009-06-28

Behavior Study of Ketamine-induced Symptoms Similar to Schizophrenia in Mice

LIU WEI-LI1,BIAN SHI-ZHONG1,GU ZHEN-LUN2,3,JIANG XIAO-GANG2,3,GUO CI-YI2,ZHAO YAN-BO4(1.DEPARTMENT OF FORENSIC MEDICINE,MEDICAL COLLEGE OF SOOCHOW UNIVERSITY,SUZHOU 215123,CHINA;2.SUZHOU INSTITUTE OF CHINESE MATERIA MEDICA,SUZHOU 215006,CHINA;3.LABORATORY   

  • Online:2009-06-25 Published:2009-06-28

摘要： 目的对氯胺酮单次或连续给药后小鼠所产生的类似精神分裂症症状进行观察,以评价不同剂量氯胺酮造模的可行性。方法40只雄性昆明种小鼠,随机分为生理盐水对照组、氯胺酮小剂量(25mg/kg)、中剂量(50mg/kg)和大剂量(100mg/kg)组,腹腔注射给药,1次/d,连续7d。观察小鼠的行为学变化。结果单次注射氯胺酮后,大剂量组小鼠有明显的运动亢进、刻板行为及共济失调现象(P<0.01);连续注射7d氯胺酮后,中剂量组小鼠出现了运动亢进、刻板行为及共济失调(P<0.05),大剂量组小鼠刻板行为及共济失调现象更为显著(P<0.01)。结论单次或连续注射氯胺酮均可诱导小鼠产生类似精神分裂症的症状,且大剂量时症状更为显著,连续注射后症状更为稳定。

关键词: 司法精神病学, 精神分裂症, 氯胺酮, 神经行为学表现, 小鼠

Abstract: Objective To observe the symptoms similar to schizophrenia in mice after ketamine single or continuous injection and to evaluate the feasibility of schizophrenia model injected with different dose of ketamine.Methods A total of 40 male mice were randomly divided into 4 groups,which were injected intraperitoneally with physiological saline(control group),25 mg/kg ketamine(low dose group),50 mg/kg ketamine(middle dose group),and 100 mg/kg ketamine(high dose group) qd for 7 days continuously.The behavior changes of mice were observed.Results Hyperactivity,stereotyped behavior and ataxia(P<0.01) were observed in high dose group after single injection.After continuous injection of ketamine for 7 days,the middle dose group showed hyperactivity,stereotyped behavior and ataxia(P<0.05),stereotyped behavior and ataxia were more significant in high dose group(P<0.01).Conclusion Ketamine can induce the symptoms similar to schizophrenia in mice after single or continuous injection.The symptoms induced by high dose ketamine will be more prominent and stable after continuous injection.

Key words: forensic psychiatry, schizophrenia, ketamine, neurobehavioral manifestations, mice