Abstract: Objective To develop a specific CZE method for the determination of methamphetamine in whole blood after solid phase extraction. Methods With the doxapram as internal standard, Oasis column was used to extract drugs from whole blood and the sample was analysized by CZE. Results The method showed excellent linearity and the linear correlation coefficient was 0.994. The relative standard deviation for between-day and within-day were 5.31% and 2.22%, respectively. Conclusion The method is effective, simple, reliable and has been used in the determination of methamphetamine in whole blood.

Key words: methamphetamine, whole blood, SPE, CZE