Abstract: Objective To improve the successful rate of operation and the livability in establishing acute myocardial ischemic rat model. Methods The successful rate of animal experiment is compared between traditional method and improved method. Results The successful rate of improved method was 90%, which was much higher than 30% in successful rate of traditional method. Conclusion The improved method may reduce the difficulty of operation remarkably and cut down the experiment expenditure, which is superior to traditional method.

Key words: rat, myocardial ischemic, model